Results 101 to 110 of about 9,665,153 (294)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Ethnic Studies Newsletter Vol. 2 No. 4

open access: yes, 1982
Four page newsletter from the Ethnic Studies department dated April 1982. Newsletter is Volume 2, Number 4. Newsletter features profile of Dr. Carolyn Naylor; Tenth Annual Conference on Minority and Ethnic Studies; Rev.
Ethnic Studies Department;
core   +1 more source

Ethnic patriotism and markets in African history

open access: yes, 2012
African economic and social history since 1800 suggests that the relationships between ethnic consciousness and market transaction is very varied and largely unpredictable. The early twentieth century was a period of important change. Before 1900 labour was scarce and land abundant: inter-ethnic relations were relatively flexible, thanks to a general ...
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

ОЙРАТЫ ЗАПАДНОЙ МОНГОЛИИ И СЕВЕРО-ЗАПАДНОГО КИТАЯ: ВОПРОСЫ ЭТНИЧЕСКОЙ ИСТОРИИ, ДЕМОГРАФИИ И ГЕОГРАФИИ РАССЕЛЕНИЯ ВО ВТОРОЙ ПОЛОВИНЕ XVIII ВЕКА

open access: yesOriental Studies, 2018
The author of this article gives the review of ethnic history of Oyrats of the western Mongolia and northwest China in second half of the XVIII century.
Utash Borisovich Ochirov
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Ethnic Studies Newsletter Vol. 3 No. 1

open access: yes, 1982
Seven page newsletter from the Ethnic Studies department dated October 1982. Newsletter is Volume 3, Number 1. Newsletter includes Feature on Dr. Herbert Aptheker; Feature on Dr.
Ethnic Studies Department;
core   +1 more source

On the methodology of palaeohistorical reconstructions

open access: yesПоволжская археология, 2015
Investigations into the pre-written history embracing more than 95% of the history of mankind (prehistory / palaeohistory) differs in terms of its sources and methods from the history taken in its narrow meaning, relying principally on the written ...
Vladimir V. Napolskikh
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Ethnic Studies Newsletter Vol. 7 No. 1

open access: yes, 1986
Seven page newsletter from the Ethnic Studies department dated Fall 1986. Newsletter is Volume 7, Number 1. Newsletter includes Feature on Joan Guillory; Faculty Accomplishments; News Items consisting primarily of events and organizations; and list of ...
Ethnic Studies Department;
core   +1 more source

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