Results 81 to 90 of about 8,556,350 (292)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Traditiones, 2011 This article presents the work of Georgi Sava Rakovski (1821–1867), one of the most outstanding, well-rounded, and interesting personalities of the Bulgarian Revival.
Valentina Ganeva-Raycheva
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Ethnic Studies Newsletter Vol. 2 No. 4
, 1982 Four page newsletter from the Ethnic Studies department dated April 1982. Newsletter is Volume 2, Number 4. Newsletter features profile of Dr. Carolyn Naylor; Tenth Annual Conference on Minority and Ethnic Studies; Rev.
Ethnic Studies Department;
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Ethnic Studies Newsletter Summer 1992
, 1992 Sixteen page newsletter from the Ethnic Studies department dated Summer 1992. Newsletter includes articles titled Rodney King Beating: The Racist Verdict; 500 Years of Raza Resistance; Outrage at Racist Verdict; and A Word About the International Indian
Ethnic Studies Department;
core +1 more source
Oriental Studies, 2018 This article deals with the history of an ethnic group deed lamin shevnr from the Yandykovskiy ulus of the Kalmyk steppe in the XIX-th century. The problems of the status of the shabiners of owned states uluses of Kalmykia are covered in this research.
Valeriy Batyrov
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Ethnic Studies Newsletter Vol. 5 No. 1
, 1984 Six page newsletter from the Ethnic Studies department dated Fall 1984. Newsletter is Volume 5, Number 1. Newsletter includes Feature on Dr. Joyce E. King; news items on Progress on S.C.
Ethnic Studies Department;
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source