Results 61 to 70 of about 481,141 (354)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Ethnic Minority Immigrants and their Children in Britain [PDF]
According to the 2001 UK Census ethnic minority groups account for 4.6 million or 7.9 percent of the total UK population. The 2001 British Labour Force Survey indicates that the descendants of Britain's ethnic minority immigrants form an important part ...
Christian Dustmann +1 more
core +3 more sources
The democratic engagement of Britain's ethnic minorities [PDF]
, 2014 Democratic engagement is a multi-faceted phenomenon that embraces citizens' involvement with electoral politics, their participation in ‘conventional’ extra-parliamentary political activity, their satisfaction with democracy and trust in state ...
Almond Gabriel +12 more
core +1 more source
Humanities & Social Sciences CommunicationsThis study explores the association of secondary vocational education (SVE) on subjective class identification in China, focusing on comparisons with compulsory and academic high school education, and analyzing regional and historical variations.
Penghui Wu, Ming Zhang, Demei Yang
doaj +1 more source
LandLand use and land cover (LULC) changes are the primary drivers of ecosystem transformation and have substantial impacts on local livelihoods. However, most research has focused on assessing the intensity of these changes in specific regions using ...
Siru A +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Vietnam Journal of Education, 2020 Among popular teaching approaches, teaching by module is attracting educationers. In education, the module approach is linked to the teaching technology ideology, which is a modern way of structuring or organizing the compilation of teaching content so ...
Trung Tran, Done Sophida
doaj
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Characterizations of Pacific Island people in the New Zealand press [PDF]
, 2005 Researchers have documented how ethnic minorities are often disadvantaged in mainstream media coverage, which function to silence minority voices and to privilege majority voices.
Barnett, Alison Reremoana +5 more
core +1 more source