Results 61 to 70 of about 77,978 (264)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Significantly Increased Public Interest in Sleep Disorder during the COVID-19 Pandemic: An Analysis of Google Trends Data

Journal of Education, Health and Sport
Background: The COVID-19 pandemic has had a profound impact on sleep disorders. Previous studies have shown that people's sleep time is delayed. Methods: Analyze the public's interest to the keyword "sleep disorder" during the COVID-19 pandemic from ...
Qinyi Tan, Xiaolu Chen, Yidan Cui, Hao Sun, Luyan Teng   +4 more
doaj   +1 more source

Ethnic conflict regulation and Lithuanian experience in the last decade

Politologija, 2000
There exists a rather generally accepted view that ethnic diversity of a polity is an additional source of internal instability and sometimes negatively affects the state's international standing.
Nortautas Statkus
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Analysis on the semantic evolution of Chinese Gan dialect from the perspective of cognition

SHS Web of Conferences, 2016
The meaning of a word is the reflection of social life, and it is the result of the cognition of the object, phenomenon and relationship through the mental activity. The development and changes of lexical mean-ings essentially reflect the development and
Xiao Jiugen, Chen Xijuan, Xiong Lingjun
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

How does population aging affect farmer households’ land transfer decision? Based on the China family panel studies

Frontiers in Sustainable Food Systems
The rural population is rapidly aging, and this trend may significantly reshape agricultural land management. Maintaining it is therefore both a key priority and a major challenge for the rural revitalization strategy.
Xiaoyang Xia, Yuzheng Zhang, Bingxue Xie, Xin Yang, Jiaxi Han   +4 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Primary school teachers are immune: a journey in the sea of psychological well-being, buoyancy, and engagement

BMC Psychology
The concept of language teacher immunity is a relatively new notion that has been introduced in the field of language teacher psychology. It is imperative that teachers have their inherent immunity strengthened since they have never been intrinsically ...
Zhihan Chen
doaj   +1 more source