Results 61 to 70 of about 756,284 (309)

Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells

Scientific Reports
Helicobacter pylori (H. pylori) is one of the most common bacterial infections in the world, and its key virulence component CagA is the leading cause of gastric cancer.
Dingyu Chen, Lixia Wu, Xi Liu, Qinrong Wang, Shuqin Gui, Liya Bao, Zhengrong Wang, Xiaofeng He, Yan Zhao, Jianjiang Zhou, Yuan Xie   +10 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Introduction [PDF]

, 1982
This issue of Explorations in Ethnic Studies brings into focus the vision NAIES has had from the onset, i.e., the pursuit of ”explorations and solutions” to problems within the context of oppression as they relate to the coloured ethnic minority ...
Irby, Charles C.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Investigation on Rational Utilization of Medicinal Plant Semiliquidambar cathayensis Chang Leaf and Bark at Different Developmental Stages

Metabolites
Background: Semiliquidambar cathayensis Chang is an extremely valuable and endangered medicinal plant. To investigate the exploitation and rational utilization of S.
Juanling Li, Zhaopeng Geng, Yuanyuan Yuan, Minjuan Wang, Yanan Zhang, Junli Wang   +5 more
doaj   +1 more source

Pharmacogenomics and Ethnic Minorities [PDF]

The Pharmacogenomics Journal, 2001
It could be argued our enthusiasm over pharmacogenomics is somewhat misplaced because much of the progress in public health has been due to basic measures, including improved nutrition, sanitation, and vaccination. Moreover, the diseases that plague the developed world in the 21st century, such as atherosclerosis, cancer, diabetes, and depression, have
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Ethnic Minority Immigrants and their Children in Britain [PDF]

According to the 2001 UK Census ethnic minority groups account for 4.6 million or 7.9 percent of the total UK population. The 2001 British Labour Force Survey indicates that the descendants of Britain's ethnic minority immigrants form an important part ...
Christian Dustmann, Nikolaos Theodoropoulos   +1 more
core   +3 more sources

Skilled women ethnic immigrants : is there any point at which being a multiple minority becomes an advantage, as predicted by Dual Process Theory? : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Psychology, Massey University, Auckland, New Zealand [PDF]

, 2017
Previous research on bias has focused on selection bias in recruitment. This research explores the issue of Treatment Bias (lack of advancement or promotion opportunities).
Madambi, Farai
core