Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Disproportionate Minority Contact: Alameda County [PDF]
, 2008 This FOCUS explores racial and ethnic disproportion in the juvenile justice system. A case study of Alameda County, California, examines Disproportionate Minority Contact (DMC) at various points in the system and its implications. The study is juxtaposed
Isami Arifuku, Sharan Dhanoa
core
An Underpinning of School Inequities: Asthma Absences and Lost Revenue in California Schools. [PDF]
, 2020 BACKGROUND:Asthma is epidemic in many locations in the United States. Asthma exacerbations pose serious health and education risks for students through school absences, school dropout, and introduction to the juvenile justice system.
Brindis, Claire D +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
[Review of] R. H. Barnes. Two Crows Denies It: A History of Controversy in Omaha Sociology [PDF]
, 1985 The subtitle of this book clearly reflects the scope of work Barnes sets out to accomplish. It also suggests that the study is aimed at a disciplinary readership consisting of anthropologists, sociologists, and some social historians more than an ...
Gradwohl, David M.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
‘A state of one’s own’: secessionism and federalism in India [PDF]
, 2006 Ever since the 'ethnic explosion' and secessionism blasted across the world in the mid-1980s, theorists have worked overtime to devise solutions to what appears to be an intractable problem.
Chandhoke, Neera
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
COMPARISONS OF HISPANIC HOUSEHOLDS' DEMAND FOR MEATS WITH OTHER ETHNIC GROUPS [PDF]
The objective of this research was to analyze the demand patterns of Hispanic households for meats in comparison with other ethnic groups using data from the 1998 Consumer Expenditure Survey.
Ames, Glenn C.W. +2 more
core +1 more source