Results 101 to 110 of about 20,342 (251)

PERBEDAAN PENGARUH PEMBERIAN PROPOFOL DAN ETOMIDATE TERHADAP KADAR PROCALCITONIN PADA OPERASI MASTEKTOMI [PDF]

, 2012
Background: Patients who major surgery with general anesthesia are greatly in risk of post-operative sepsis and Systemic Inflamatory Response Syndrome (SIRS). One of the marker that can be used to check it is procalcitonin. Anesthetic induction medicines
BASKARA, ENDRIK, Istanto N, Widya, Nur R.S, Adhie   +2 more
core  

Emerging methods for subtype differentiation in primary aldosteronism

Journal of Internal Medicine, Volume 299, Issue 2, Page 178-195, February 2026.
Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson, C. Christofer Juhlin, Tobias Åkerström, Per Dahlqvist, Henrik Falhammar, Per Hellman   +5 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands [PDF]

, 2019
The synaptic α1β2γ2 ...
Akk, Gustav, Burbridge, Ariel B, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Steinbach, Joe Henry   +5 more
core   +1 more source

Scientometrics of anesthetic drugs and their techniques of administration, 1984–2013 [PDF]

, 2015
The aim of this study was to assess progress in the field of anesthetic drugs over the past 30 years using scientometric indices: popularity indices (general and specific), representing the proportion of articles on a drug relative to all articles in the
Kissin, Igor, Vlassakov, Kamen V
core   +1 more source

Exception from Informed Consent and Waiver of Informed Consent for Comparative Effectiveness Trials in Emergency Care Research

Ethics &Human Research, Volume 48, Issue 1, Page 31-41, January–February 2026.
ABSTRACT For many of the decisions made in the clinical care setting, clinicians lack evidence to inform which treatment would result in the best patient outcomes. This problem is particularly common in emergency care, a field in which the condition of the patient and the urgent nature of the treatment often preclude research conducted using ...
Jonathan D. Casey, Matthew W. Semler, Jeremy Brown, Clifton W. Callaway, Stephanie C. DeMasi, Neal W. Dickert, Luke Gelinas, Francis X. Guyette, Ann R. Johnson, Wesley H. Self, Todd W. Rice, Stephanie R. Morain   +11 more
wiley   +1 more source

Anesthetic choice matters: a retro-prospective analysis of propofol vs etomidate on seizure and recovery parameters in modified electroconvulsive therapy

Middle East Current Psychiatry
Modified electroconvulsive therapy is a highly effective treatment for various disorders. Its effectiveness depends both on stimulus parameters and anesthetic agent.
Neelofer Jan, Iqra Arshad, Arjuman Fayaz, Rayees Najib, Inaam ul-Haq, Yasir Hassan Rather, Altaf Ahmad Malla   +6 more
doaj   +1 more source

Antifungal activity of etomidate against growing biofilms of fluconazole-resistant Candida spp. strains, binding to mannoproteins and molecular docking with the ALS3 protein.

Journal of Medical Microbiology, 2020
This study evaluated the effect of etomidate against biofilms of Candida spp. and analysed through molecular docking the interaction of this drug with ALS3, an important protein for fungal adhesion.
Lívia Gurgel do Amaral Valente Sá, C. D. da Silva, J. B. A. Neto, Francisca Bruna Stefany Aires do Nascimento, F. Barroso, L. J. da Silva, V. P. D. F. Cabral, A. D. Barbosa, Jacilene Silva, E. S. Marinho, M. D. de Moraes, Maria Erivanda França Rios, B. Cavalcanti, Iri Sandro Pampolha Lima, H. V. N. Júnior   +14 more
semanticscholar   +1 more source

Selective inhibition of extra-synaptic α5-GABA_A receptors by S44819, a new therapeutic agent [PDF]

, 2017
In the mammalian central nervous system (CNS) GABAA receptors (GABAARs) mediate neuronal inhibition and are important therapeutic targets. GABAARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression of 20-30 GABAAR subtypes.
Adam R. Brown, Adrienn Pálvölgyi, Atack, Balázs Mihalik, Barker, Belelli, Ben G. Gunn, Bergmann, Bolognani, Bonin, Botta, Brown, Brown, Brown, Capogna, Caraiscos, Clarkson, Cobb, Darmani, Delia Belelli, Drexel, Ferenc A. Antoni, Fisahn, Fritschy, Gacsályi, Gacsályi, Hausrat, Herd, Herd, Huerta, István Gacsályi, István Ling, Jeremy J. Lambert, Jones, József Barkóczy, Karayannis, Katalin Pallagi, Keene, Kinnavane, Knust, Lake, Lerma, Ling, Ling, Lori-An Etherington, Lüddens, Maconochie, Martin, Matthew R. Livesey, Mendez, Michael Spedding, Mihalik, Milic, Neves, Olivia Monteiro, Olsen, Peden, Pirker, Prenosil, Péter Varga, Redrobe, Rudolph, Salesse, Salmon, Serwanski, Szabolcs Kertész, Thompson, Ueno, Wang, Wisden, Wlodarczyk, Wu, Zarnowska, Zhang, Zurek   +74 more
core   +2 more sources

Clinical predictors of seizure threshold in electroconvulsive therapy: a prospective study [PDF]

, 2012
At the start and during the course of electroconvulsive therapy (ECT), estimation of the seizure threshold (ST) is useful in weighing the expected effectiveness against the risks of side effects. Therefore, this study explores clinical factors predicting
Bastiaan Verwey, Erik J. Giltay, Jeroen A. van Waarde, Lucas J. B. van Oudheusden, Rose C. van der Mast   +4 more
core   +2 more sources