Results 111 to 120 of about 9,607 (202)

Mapping General Anesthetic Binding Site(s) in Human α1β3 γ-Aminobutyric Acid Type A Receptors with [³H]TDBzl-Etomidate, a Photoreactive Etomidate Analogue

, 2016
The γ-aminobutyric acid type A receptor (GABAAR) is a target for general anesthetics of diverse chemical structures, which act as positive allosteric modulators at clinical doses.
Selwyn S. Jayakar (2119426), David C. Chiara (1858402), Keith W. Miller (187916), Jonathan B. Cohen (1858411), Xiaojuan Zhou (2060539), Zuzana Dostalova (2119423)   +5 more
core   +1 more source

EVALUATION OF ETOMIDATE

British Journal of Anaesthesia, 1979
J G, Hendry, N W, Lees, B M, Miller
openaire   +2 more sources

Impact of anesthetic induction with etomidate, thiopentone, and propofol on regional cerebral oxygenation: An observational study in patients with traumatic brain injury

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Anesthetic induction plays a pivotal role in determining the operative course and the outcome in patients with acute traumatic brain injury (TBI).
Kunal K. Sharma, Rohini M. Surve, K. R. Madhusudan Reddy, Rita Christopher, Dhritiman Chakrabarti, Sundaravadivel Pandarisamy, Shruti V. Palakuzhiyil, Sriganesh Kamath   +7 more
doaj   +1 more source

A randomized clinical trial comparing hemodynamic responses to ketamine-propofol combination (ketofol) versus etomidate during anesthesia induction in patients with left ventricular dysfunction undergoing coronary artery bypass graft surgery

, 2016
Introduction : Anesthesia induction is often accompanied by a period of hemodynamic instability, which could be a significant problem in patients with compromised ventricular function.
Sajedeh Rashidaei, Amir Emami Zeydi, Afshin Gholipour Baradari, Abbas Alipour, Mohammad Reza Habibi   +4 more
core   +1 more source

The Comparison of the Efficacy and Safety of Sedation with Etomidate-Fentanyl versus Ketamine-Midazolam Combinations in Cataract Surgery

مجله دانشکده پزشکی اصفهان, 2012
Background: Etomidate and ketamine are commonly used to induce sedation in cataract surgery due to their favorable hemodynamic side-effect profile. This study was performed to compare the efficacy and safety of etomidate/fentanyl with ketamine/midazolam ...
Omid Aghadavoudi, Parastou Balaei, Mojtaba Akbari   +2 more
doaj  

Etomidate Improves Antitumor Immunity by Suppressing PD-L1 Expression in Hepatocellular Carcinoma CellsSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Etomidate, a prevalent intravenous anesthetic agent, has been implicated in the attenuation of tumorigenesis. Our recent investigations elucidated its capacity to impede the malignant progression of hepatocellular carcinoma (HCC ...
Jiali Xu, Qing Ji, Yining Chen, Yu Xu, Zhihui Wang, Zhenyu Yuan, Dapeng Gao, Lidong Zhang, Cunming Liu, Qing Li, Liren Zhang, Jingjing Dai   +11 more
doaj   +1 more source

Etomidate in severe cushing syndrome: a systematic review [PDF]

Background Severe Cushing syndrome is a medical emergency. Etomidate is the only IV option available for treating hypercortisolism, especially in critically ill patients obviating oral medications.
Mahesh, P.K.B., Newell-Price, J., Muthukuda, D.T., Ruwanga, V.G.D., Liyanaarachchi, K.D., Jayawickreme, K.P., Kumar, S., Subasinghe, C.   +7 more
core   +1 more source

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

, 2003
General anaesthetics exhibiting enantioselectivity afford valuable tools to assess the fundamental mechanisms underlying anaesthesia. Here, we characterised the actions of the R-(+)- and S-(-)-enantiomers of etomidate.
Muntoni, A L, Gentet, Luc J., Merrywest, S D, Callachan, H, Gemmell, David K., Lambert, J J, Sillar, K T, Lambert, Jeremy J., Muntoni, Anna-Lisa, Callachan, Helen, Peters, John A., Hamilton, Niall M., Sillar, Keith T., Madau, P, Gemmell, D K, Belelli, D, Casula, Anna, Gentet, L J, Casula, A, Merrywest, Simon D., Peters, J A, Madau, Paola, Belelli, Delia, Hamilton, N M   +23 more
core   +1 more source

Comparative study of intravenous etomidate versus propofol during induction and

, 2020
Introduction: Safe induction of anesthesia is important part of anesthesia practice as life threatening hemodynamic variations may occur during induction and intubation in hemodynamically unstable patients.
Goyal, Sameer, Barya, Smita, Garg, Ankush Kumar   +2 more
core  

Etomidate and its derivatives: time to say goodbye?

Etomidate, an intravenous hypnotic used for anaesthesia and critical care, is known for its undesirable side effects, including pain on injection, myoclonus, and adrenocortical depression.
Sneyd, J Robert, Valk, Beatrijs I., Valk, Beatrijs, Sneyd, J. Robert   +3 more
core   +1 more source