Results 1 to 10 of about 124,631 (174)

Gut bacterial O-demethylation modulates systemic exposure to oral etoposide [PDF]

Gut Microbes
Gut microbial O-demethylation has been reported for plant-derived dietary compounds containing O-methylated aromatic(s). However, the significance of gut microbial O-demethylation in drug metabolism and disposition remains unexplored. This study examined
Ashutosh Tripathi, Toe Ein Kyawt, Jongoh Shin, Kyoung-jae Won, Abigail T. Armstrong, Giokdjen Ilktach, Peter Sullivan, Holly A. Weilbaker, Yeonju Ko, Seongsoo Lee, Wooin Lee, Bruce R. Cooper, Byung-Kwan Cho, Jimmy Orjala, Hyunwoo Lee, Hyunyoung Jeong   +15 more
doaj   +2 more sources

Ameliorative potential role of Rosmarinus officinalis extract on toxicity induced by etoposide in male albino rats [PDF]

Brazilian Journal of Biology, 2022
The present work was showed to assess the effect of administration of rosemary extract on etoposide-induced toxicity, injury and proliferation in male rats were investigated. Forty male albino rats were arranged into four equal groups. 1st group, control;
Reham M morsi, Doaa S. Mansour, Amr M. Mousa   +2 more
doaj   +1 more source

Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play

Translational Oncology, 2021
Etoposide is a semi-synthetic glycoside derivative of podophyllotoxin, also known as VP-16. It is a widely used anticancer medicine in clinics. Unfortunately, high doses or long-term etoposide treatment can induce therapy-related leukemia.
Wenchao Zhang, Panhong Gou, Jean-Marie Dupret, Christine Chomienne, Fernando Rodrigues-Lima   +4 more
doaj   +1 more source

Anlotinib plus etoposide increases survival in patients with small-cell lung cancer after chemoradiotherapy

Journal of Radiation Research and Applied Sciences, 2022
Objectives: Small-cell lung cancer is a recalcitrant subtype of lung cancer with rapid progression and high metastasis. This study compared the efficacy of anlotinib plus etoposide with etoposide alone for extensive-stage small-cell lung cancer after ...
Lizhen Gao, Junqing Wang, Junlin Chen, Xuelin Zhang, Manman Zhang, Suling Wang, Chen Zhao   +6 more
doaj   +1 more source

Cross-allergic reactions between etoposide and penicillin in autologous bone marrow transplant patient

Iraqi Journal of Hematology, 2022
Etoposide is a chemotherapeutic agent that belongs to the podophyllotoxin drug class. Etoposide is used in treating many types of cancers including blood cancers.
Alaa Hussein Alsajri, Mazin Abbas Shubber, Walid Al-Qerem   +2 more
doaj   +1 more source

The role of etoposide in the treatment of adult patients with hemophagocytic lymphohistiocytosis

Experimental Hematology & Oncology, 2023
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal inflammatory clinical condition, in which an exaggerated immune response is ineffectively regulated.
Timo C. E. Zondag, Aglina Lika, Jan A. M. van Laar   +2 more
doaj   +1 more source

Human Lactoferrin Synergizes with Etoposide to Inhibit Lung Adenocarcinoma Cell Growth While Attenuating Etoposide-Mediated Cytotoxicity of Human Endothelial Cells

Biomedicines, 2022
Lung cancer continues to be the deadliest cancer worldwide. A new strategy of combining chemotherapeutics with naturally occurring anticancer compounds, such as lactoferrin, might improve the efficacy and toxicity of current chemotherapy. The aim of this
Paulina Olszewska, Barbara Pazdrak, Marian L. Kruzel   +2 more
doaj   +1 more source

Numerical analysis of etoposide induced DNA breaks. [PDF]

PLoS ONE, 2009
BACKGROUND:Etoposide is a cancer drug that induces strand breaks in cellular DNA by inhibiting topoisomerase II (topoII) religation of cleaved DNA molecules.
Aida Muslimović, Susanne Nyström, Yue Gao, Ola Hammarsten   +3 more
doaj   +1 more source

Study of the Toxic Manifestation of Etoposide the Concomitant Exposure of Acetyl Salicylic Acid As a Protector on the Example of C57Bl/6J Mice Line

Антибиотики и Химиотерапия, 2023
The paper presents the results of evaluating the genetic and cytogenetic toxicity of etoposide, as well as the evaluation results of protective properties of aspirin against the toxicity of etoposide in C57Bl/6J mice.
O. N. Antosyuk, A. V. Gorskaya, D. V. Petrovskii, T. D. Dubatolova   +3 more
doaj   +1 more source

Effectiveness and safety of first-line immune checkpoint inhibitors for patients with extensive-stage small cell lung carcinoma: A systematic review and network meta-analysis

Heliyon, 2023
Objective: In recent years, the introduction of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of extensive-stage small cell lung carcinoma (ES-SCLC), but the optimal combination of ICI and standard chemotherapy strategy is yet to ...
Jincheng Du, Xinyu Wang, Liwen Fan, Xinyuan Shan, Muyao Li, Linlin Liu   +5 more
doaj   +1 more source