Results 181 to 190 of about 1,734 (254)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Multifaceted Vision of Challenges and Opportunities in Practical Artificial Photosynthesis Devices. [PDF]

Artif Photosynth
Perathoner S, Li C, Wang J, Li R, Wang W, Centi G, Romano V.   +6 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Drug-induced gingival overgrowth: FAERS based real-world pharmacovigilance study and network pharmacology analysis. [PDF]

Front Pharmacol
Zhu Q, Wu Z, Jiao X, Han L, Yuan Y.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Pseudomonas putida JM37 as a novel bacterial chassis for ethylene glycol upcycling

Molpeceres-García FJ, García-Miró A, Mateos E, Prieto A, Sanz D, Jiménez JI, Barriuso J.   +6 more
europepmc   +1 more source

A Pollution Detection System for Plastic Ocean Waste Based on Energy-Harvesting Radio Transmitters. [PDF]

Sensors (Basel)
Beschastnyi V, Ostrikova D, Samouylov K.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A direct black-hole mass measurement in a little red dot at high redshift. [PDF]

Nature
Juodžbalis I, Marconcini C, D'Eugenio F, Maiolino R, Marconi A, Übler H, Scholtz J, Ji X, Jones GC, Perna M, Arribas S, Bennett JS, Bromm V, Bunker AJ, Carniani S, Charlot S, Cresci G, Dayal P, Egami E, Fabian A, Inayoshi K, Isobe Y, Ivey LR, Koudmani S, Laporte N, Liu B, Lyu J, Mazzolari G, Monty S, Parlanti E, Pérez-González PG, Robertson B, Schneider R, Sijacki D, Tacchella S, Trinca A, Valiante R, Volonteri M, Witstok J, Zhang S.   +39 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source