Results 201 to 210 of about 1,725 (256)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Mechanistic insights into E. coli recovery from growth arrest. [PDF]

Nat Commun
Hassan AH, Nakano Y, Gamper H, Masuda I, Vesela L, Pinkas M, Nagarajan SN, Dworkin J, Blaha G, Hou YM, Demo G.   +10 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Interoperable Traceability in Agrifood Supply Chains: Enhancing Transport Systems Through IoT Sensor Data, Blockchain, and DataSpace. [PDF]

Sensors (Basel)
Farina G, Kocian A, Brunori G, Chessa S, Lai MB, Nardi D, Schifanella C, Bonura S, Masi N, Comella S, Ambrosino F, Mariano A, Colizzi L, Dimitri GM, Gori M, Scarselli F, Bonomi S, Almici E, Antiga L, Fiorentino AS, Moreschi L.   +20 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Novel archaeal ribosome dimerization factor facilitating unique 30S-30S dimerization. [PDF]

Nucleic Acids Res
Hassan AH, Pinkas M, Yaeshima C, Ishino S, Uchiumi T, Ito K, Demo G.   +6 more
europepmc   +1 more source

EU geographical islands as leaders of green energy transition. [PDF]

Open Res Eur
Bonvicini G, Roccatagliata F, Cortese M, Karanasios K, Kotsampopoulos P, Sainz F, Ganzinelli N, Montanelli A, Battistelli F, Barbero C, Ghiani E, Ruffini S, Cuneo A.   +12 more
europepmc   +1 more source

FEDECOM: Enabling cross-border energy exchange by federating energy communities. [PDF]

Open Res Eur
Lennard Z.
europepmc   +1 more source