Results 151 to 160 of about 3,703 (283)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Seed Treatment Alternatives with Improved Ecological Profiles for Controlling Wireworms in Maize and Early-Season Sugar Beet Pests. [PDF]

Plants (Basel)
Bažok R, Lemić D, Bubalo D, Kasap A, Vojvodić M.   +4 more
europepmc   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A review of European-funded projects implementing living labs for the sustainability of agri-food systems. [PDF]

Sci Data
Ferrara A, Göldel B, Arcuri S, Galli F, Massari S, Gallo G, Mignani C, Vergamini D, Cavicchi A.   +8 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform. [PDF]

Sci Rep
Ali M, Smiriglia R, Spera E, Mirani SA, Solinas SMG, Migliore M, Ascoli GA, Bologna LL.   +7 more
europepmc   +1 more source

Emerging Breeding Blanket Variants for the EU DEMO

, 2023
Hernández, F. A., Arena, P., Bongiovi, G., Catanzaro, I., Cerviño, C.A., D’Amico, S., Del Nevo, A., Maio, P.A. Di, Garnier, C., Giambrone, S., Marugán, J.C., Moscato, I., Palermo, I., Pereslavtsev, P., Quartararo, A., Urgorri, F. R., Spagnuolo, G.A., Tassone, A., Zhou, G.   +18 more
openaire   +3 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

How to get the most out of fungal biotechnology? [PDF]

Fungal Biol Biotechnol
Nygård Y, Meyer V.
europepmc   +1 more source