Results 211 to 220 of about 152,993 (306)

Rational design and synthesis of narrow-band emitting Eu(II)-based hybrid halides via alkyl thermal cleavage. [PDF]

Nat Commun
Li L, Jin J, Han K, Wang Y, Xia Z.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pseudomonas putida JM37 as a novel bacterial chassis for ethylene glycol upcycling

Molpeceres-García FJ, García-Miró A, Mateos E, Prieto A, Sanz D, Jiménez JI, Barriuso J.   +6 more
europepmc   +1 more source

Interoperable Traceability in Agrifood Supply Chains: Enhancing Transport Systems Through IoT Sensor Data, Blockchain, and DataSpace. [PDF]

Sensors (Basel)
Farina G, Kocian A, Brunori G, Chessa S, Lai MB, Nardi D, Schifanella C, Bonura S, Masi N, Comella S, Ambrosino F, Mariano A, Colizzi L, Dimitri GM, Gori M, Scarselli F, Bonomi S, Almici E, Antiga L, Fiorentino AS, Moreschi L.   +20 more
europepmc   +1 more source

Spain at the vanguard in European gender equality policies [PDF]

, 2008
Valiente Fernández, Celia
core   +2 more sources

Implementation of the EU-DEMO Exhaust Modelling Roadmap

, 2022
Wiesen, S, Aho-Mantila, L, Dasbach, S, Matveev, D, Romazanov, J, Wischmeier, M, Osawa, R, Subba, F:, Coleman, M, Maviglia, F, Siccinio, M, Zohm, H, Bernert, M, Brezinsek, S   +13 more
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Novel archaeal ribosome dimerization factor facilitating unique 30S-30S dimerization. [PDF]

Nucleic Acids Res
Hassan AH, Pinkas M, Yaeshima C, Ishino S, Uchiumi T, Ito K, Demo G.   +6 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source