Results 31 to 40 of about 444 (212)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Energy commodities spillover analysis for assessing the functioning of the European Union Emissions Trading System trade network of carbon allowances

open access: yesScientific Reports
The European Union Emissions Trading System (EU ETS) is designed to promote carbon reduction in a cost-effective and economically efficient manner.
Andrea Flori
doaj   +1 more source

Industrial carbon emission intensity: A comprehensive dataset of European regions

open access: yesData in Brief, 2021
The dataset has been developed within the framework of the EU EIT-Climate Kic Flagship Project “Re-Industrialise” and it includes data of Carbon Emission Intensity (CEI) from industrial sources for the European Regions.
Matteo Mura   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

Determinación por procedimientos físico-mecánicos de la dosificación de agua en morteros monocapa. Su incidencia en la aparición de patologías en la obra terminada

open access: yesInformes de la Construccion, 2007
Los morteros de revestimiento monocapa tienen entre sus componentes diversos aditivos y adiciones en proporciones variables, según cada fabricante. De este modo, cada mortero monocapa puede calificarse como único. En este artículo se presentan una serie
Pablo Luis Mayor Lobo   +1 more
doaj   +1 more source

Resilience of the EU ETS to contextual disturbance: the case of EU enlargement and its impact on ETS policymaking dynamics

open access: yesEnvironmental Politics, 2022
The European Union (EU) Emissions Trading System (ETS) has been established for more than 15 years, but limited attention has been given to how the changing political environment may affect the policy. We address this gap by investigating how the EU enlargement after 2004 affected the ETS and how the effects have been buffered.
Wang, Z, Paavola, J
openaire   +2 more sources

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli   +13 more
wiley   +1 more source

IMPACT OF EU-ETS ON EUROPEAN AIRCRAFT OPERATORS

open access: yesPerner’s Contacts, 2011
In 2009 EU Directive 2003/87/EC for inclusion of aviation into the EU Emissions Trading Scheme (EU-ETS) came into force. From January 2012, the EU-ETS will cover virtually all flights departing or arriving in the EU.
Zdeněk Hanuš, Peter Vittek
doaj  

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