Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Sustainable Real Exchange Rates in the New EU Member States: What Did the Great Recession Change? [PDF]
The Great Recession affected export and import patterns in our sample of new EU member countries, and these changes, coupled with a more volatile external environment, have a profound impact on our estimates of real exchange rate misalignments and ...
Ales Bulir +2 more
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Three Worlds of Compliance or Four? The EU15 Compared to New Member States. IHS Political Science Series Paper, No. 112, March 2007 [PDF]
, 2007 Starting from the findings of an earlier compliance study covering the fifteen ‘old’ member states of the European Union, which identified three ‘worlds of compliance’, this paper seeks to establish whether or not the new member states from Central and ...
Treib, Oliver., Falkner, Gerda,
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Bratislava Law Review, 2017 The EU does not aim to harmonize the public administration of Member States, although, in recent years, there have been several examples which prove that EU legislation in whatever policy inevitably and unavoidably results in some standardization.
Erzsébet Csatlós
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
ECONOMIC CRISIS IN NEW EU MEMBER STATES IN CENTRAL AND EASTERN EUROPE: FOCUSING ON BALTIC STATES [PDF]
After giving a general view of the economic crisis in new EU member states in Central and Eastern Europe, this paper examines the causes, focusing on Baltic States, especially Latvia.
Yoji Koyama
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Agraarteadus, 2019 To identify the European Union (EU) member states strong exports sectors and food chains, the revealed comparative advantage indices from trade data were calculated using the total global trade as the benchmark of comparison.
Štefan Bojnec1, Imre Fertő
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Some impacts of the EU accession on the new member states’ agriculture [PDF]
The main aim of the paper is to analyse the impact of the EU accession on the New Member States’ agriculture with special regard to production, employment, farmers’ income and intra-EU trade in agricultural goods on the basis of the latest statistical ...
Judit KISS
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Labor migration and unemployment: what can we learn from EU rules on the free movement of workers? CEPS Liberty and Security in Europe No. 46, 7 February 2012 [PDF]
, 2012 This paper examines the impact of labour migration on unemployment in the context of the accession of Bulgaria and Romania to the EU and the EU’s rules on the free movement of workers. In particular, it addresses two questions.
Guild, Elspeth, Carrera, Sergio
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