Results 121 to 130 of about 822 (209)

Inferring three-nucleon couplings from multi-messenger neutron-star observations. [PDF]

Nat Commun
Somasundaram R, Svensson I, De S, Deneris AE, Dietz Y, Landry P, Schwenk A, Tews I.   +7 more
europepmc   +1 more source

Recent Developments at DG Competition: 2021/2022. [PDF]

Rev Ind Organ, 2022
Buettner T, Coublucq D, Kotzeva R, Sauri-Romero L, Régibeau P.   +4 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Multi-messenger gravitational lensing. [PDF]

Philos Trans A Math Phys Eng Sci
Smith GP, Baker T, Birrer S, Collins CE, Ezquiaga JM, Goyal S, Hannuksela OA, Hemanta P, Hendry MA, Janquart J, Keitel D, Levan AJ, Lo RKL, More A, Nicholl M, Pastor-Marazuela I, Ponte Pérez AI, Ubach H, Uronen LE, Wright M, Zumalacarregui M, Bianco F, Çalişkan M, Chan JCL, Colangeli E, Gompertz BP, Haines CP, Hayes EE, Hu B, Lamb GP, Liu A, Mandhai S, Narola H, Nguyen QL, Poon JSC, Ryczanowski D, Seo E, Shajib AJ, Shan X, Tanvir N, Vujeva L.   +40 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Defining early health technology assessment: reclaiming origins and diversity of applications. [PDF]

Int J Technol Assess Health Care
Goodman C.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Industry updates from the field of stem cell research and regenerative medicine in March 2025. [PDF]

Regen Med
Ilic D, Liovic M.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Competition Law and Ethics of Innovation as Catalysts for Fairness: Reimagining the EU's COVID-19 Vaccine Strategy. [PDF]

J Law Med Ethics
Hosseini M.
europepmc   +1 more source