Results 91 to 100 of about 19,515 (233)

Compensatory motor neuron response to chromatolysis in the murine hSOD1G93A model of amyotrophic lateral sclerosis

Frontiers in Cellular Neuroscience, 2014
We investigated neuronal self-defense mechanisms in a murine model of amyotrophic lateral sclerosis (ALS), the transgenic hSOD1G93A, during both the asymptomatic and symptomatic stages.
Javier eRiancho, Maria eRuiz-Soto, Nuria T Villagra, Jose eBerciano, Maria T Berciano, Miguel eLafarga   +5 more
doaj   +1 more source

Factors determining chromosomal localization of transposable elements in plants

Plant Biology, EarlyView.
We review transposon chromosomal niches, and the functional consequences of their specific chromosomal localization in plants. Abstract Transposable elements (TEs) constitute a significant part of plant genomes and shape their genomic landscape. While some TEs are ubiquitously dispersed, other elements specifically occupy discrete genomic loci.
E. Kejnovsky, P. Jedlicka, M. Lexa, Z. Kubat   +3 more
wiley   +1 more source

The maternal to zygotic transition regulates genome-wide heterochromatin establishment in the zebrafish embryo

Nature Communications, 2019
Eukaryotic genomes are segregated into euchromatin and heterochromatin. Here the authors show that heterochromatin establishment during zebrafish embryo development is controlled by zygotic transcription of miR-430 and subsequent degradation of maternal ...
Kathrin Laue, Srivarsha Rajshekar, Abigail J. Courtney, Zachary A. Lewis, Mary G. Goll   +4 more
doaj   +1 more source

Osteoarthritis: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 8, August 2025.
A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu, Ning‐Yi Guo, Jian‐Quan Wang, Bing‐Bing Xu   +3 more
wiley   +1 more source

Toll‐Like Receptors in the Immunotherapy Era: Dual‐Edged Swords of Tumor Immunity and Clinical Translation

MedComm, Volume 6, Issue 8, August 2025.
This review discussed the signaling pathways of Toll‐like receptors in tumors and their antitumor or protumor regulatory effects in diverse tumors. We also paid attention to the application of Toll‐like receptors in clinical treatment and summarized the clinical trial situation in recent years.
Nueraili Maihemuti, Yueli Shi, Kaiyue Zhang, Xinyuan Jiang, Jiahe Chu, Yun Xu, Zhiyong Xu, Kai Wang   +7 more
wiley   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1095-1102, August 2025.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 This original article is commented by Thompson on pages 975–976 of this issue. Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

Integrated Disease Management, Adaptation and Genomics of Fungal Plant Pathogens in Cropping Systems

Plant Pathology, Volume 74, Issue 6, Page 1445-1469, August 2025.
Knowledge of the fungal genome and multifaceted evolutionary forces need to be considered together in understanding and managing agricultural plant pathogen adaptation relative to integrated disease management (IDM) strategies. ABSTRACT Crop production systems contribute significantly to maintaining global food security. These systems often involve the
Hayley Wilson, Ido Bar, Kristy Hobson, Niloofar Vaghefi, Toni Petronitis, Rebecca Ford   +5 more
wiley   +1 more source

Genome-wide mapping of DNase I hypersensitive sites reveals chromatin accessibility changes in Arabidopsis euchromatin and heterochromatin regions under extended darkness

Scientific Reports, 2017
Light, as the energy source in photosynthesis, is essential for plant growth and development. Extended darkness causes dramatic gene expression changes.
Yue Liu, Wenli Zhang, Kang Zhang, Qi You, Hengyu Yan, Yuannian Jiao, Jiming Jiang, Wenying Xu, Zhen Su   +8 more
semanticscholar   +1 more source

STEMIN transcription factor drives selective chromatin remodeling for gene activation within a relaxed chromatin during reprogramming in the moss Physcomitrium patens

The Plant Journal, Volume 123, Issue 3, August 2025.
SUMMARY Land plants exhibit remarkable cellular plasticity, readily reprogramming differentiated cells into stem cells in response to internal and external stimuli. While chromatin remodeling is crucial for cellular reprogramming, its interplay with gene expression during reprogramming into stem cells remains elusive.
Ruan Morné de Villiers, Gergo Palfalvi, Akinori Kanai, Yutaka Suzuki, Mitsuyasu Hasebe, Masaki Ishikawa   +5 more
wiley   +1 more source

Dynamic chromatin changes associated with de novo centromere formation in maize euchromatin.

The Plant Journal, 2016
The inheritance and function of centromeres are not strictly dependent on any specific DNA sequence, but involve an epigenetic component in most species.
H. Su, Yalin Liu, Yong-xin Liu, Zhenling Lv, Hongyao Li, Shaojun Xie, Zhi Gao, Junling Pang, Xiu-Jie Wang, Jinsheng Lai, J. Birchler, F. Han   +11 more
semanticscholar   +1 more source