Results 101 to 110 of about 19,515 (233)
Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology
CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 282-307, July/August 2025.Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari +7 more
wiley +1 more source
Heterologous protein production using euchromatin-containing expression vectors in mammalian cells
Nucleic Acids Research, 2015 Upon stable cell line generation, chromosomal integration site of the vector DNA has a major impact on transgene expression. Here we apply an active gene environment, rather than specified genetic elements, in expression vectors used for random ...
Katalin Zboray +11 more
semanticscholar +1 more source
Active Hydrodynamic Theory of Euchromatin and Heterochromatin
The genome contains genetic information essential for cell's life. The genome's spatial organization inside the cell nucleus is critical for its proper function including gene regulation. The two major genomic compartments -- euchromatin and heterochromatin -- contain largely transcriptionally active and silenced genes, respectively, and exhibit ...
Rautu, S. Alex +3 more
openaire +2 more sources
Frontiers in Genetics, 2014 Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the ...
Michael R Foret +6 more
doaj +1 more source
Toxicological Sciences, 2015 Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair that generates toxic DNA double-strand breaks (DSBs) as ...
Z. DeLoughery +3 more
semanticscholar +1 more source
Subcellular organization of UBE3A in human cerebral cortex
Molecular Autism, 2018 Background Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Alain C. Burette +6 more
doaj +1 more source
Epigenetics & Chromatin, 2015 BackgroundDNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis.
María-Paz Ramos +4 more
semanticscholar +1 more source
Bio-Protocol, 2016 Barley is a diploid inbreeding crop with a genome of 5 GB organized into seven chromosomes. The relatively low chromosome number and their large size make barley an excellent model for chromosome cytogenetic studies of large genome cereal crops ...
Isabelle Colas +2 more
doaj +1 more source
Differential Uptake of Tritiated Thymidine into Hetero- and Euchromatin in Melanoplus and Secale [PDF]
, 1959 A. Lima-de-Faria
openalex +1 more source