Results 11 to 20 of about 15,596 (174)
The hierarchical packing of euchromatin domains can be described as multiplicative cascades.
PLoS Computational Biology, 2021 The genome is packed into the cell nucleus in the form of chromatin. Biochemical approaches have revealed that chromatin is packed within domains, which group into larger domains, and so forth.
Amra Noa +4 more
doaj +1 more source
From Effective Interactions Extracted Using Hi-C Data to Chromosome Structures in Conventional and Inverted Nuclei [PDF]
PRX Life 1, 013010 (2023), 2023 Contact probabilities between loci, separated by arbitrary genomic distance, for a number of cell types have been reported using genome-wide chromosome conformation capture (Hi-C) experiments. How to extract the effective interaction energies between active euchromatin (A) and inactive heterochromatin (B) directly from the experimental data, without an
arxiv +1 more source
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 We review here recent studies reporting the importance of both nuclear lamina components and epigenetic modifications of chromatin in nuclear mechanics. Perturbation of chromatin condensation or nuclear lamina has been linked to a plethora of biological conditions whose most studied examples are accelerated Hutchinson‐Gilford Progeria Syndrome (HGPS ...
Pietro Salvatore Carollo, Viviana Barra
wiley +1 more source
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Schematic depicting characterization of pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in neurodegenerative diseases. Abstract Accumulation of pathological tau aggregates is a prominent feature in tauopathies that leads during the course of the diseases to neuronal dysfunction before and cell death after ...
Mauro Montalbano +4 more
wiley +1 more source
The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation. [PDF]
PLoS Genetics, 2011 The chromosomes of eukaryotes are organized into structurally and functionally discrete domains. This implies the presence of insulator elements that separate adjacent domains, allowing them to maintain different chromatin structures.
Annelie Strålfors +3 more
doaj +1 more source
Scientific Reports, 2021 A characteristic spatial distribution of the main chromatin fractions is observed in most mammalian cell nuclei, with euchromatin localized in the interior and heterochromatin at the nuclear periphery.
Joanna Stachecka +3 more
doaj +1 more source
Development of Artificial System to Induce Chromatin Loosening in Saccharomyces cerevisiae
Biomolecules, 2022 In eukaryotic cells, loosening of chromatin causes changes in transcription and DNA replication. The artificial conversion of tightly packed chromatin (heterochromatin) to loosely packed chromatin (euchromatin) enables gene expression and regulates cell ...
Ryota Yamamoto +4 more
doaj +1 more source
Genomic organization of H2Av containing nucleosomes in Drosophila heterochromatin. [PDF]
PLoS ONE, 2011 H2Av is a versatile histone variant that plays both positive and negative roles in transcription, DNA repair, and chromatin structure in Drosophila.
Zhenhai Zhang, B Franklin Pugh
doaj +1 more source
TALEN outperforms Cas9 in editing heterochromatin target sites
Nature Communications, 2021 While Cas9 outperforms TALENs in euchromatin, it is less efficient in heterochromatic regions. Here the authors, using single-molecule imaging, show that Cas9 uses a less efficient search strategy compared to TALENs in these regions.
Surbhi Jain +12 more
doaj +1 more source
mBio, 2019 Eukaryotic genomes are packaged into chromatin structures that play pivotal roles in regulating all DNA-associated processes. Histone posttranslational modifications modulate chromatin structure and function, leading to rapid regulation of gene ...
Robert Jordan Price +3 more
doaj +1 more source