Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus [PDF]
NucleusAbnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar +3 more
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Replication of the Mammalian Genome by Replisomes Specific for Euchromatin and Heterochromatin [PDF]
Frontiers in Cell and Developmental Biology, 2021 Replisomes follow a schedule in which replication of DNA in euchromatin is early in S phase while sequences in heterochromatin replicate late. Impediments to DNA replication, referred to as replication stress, can stall replication forks triggering activation of the ATR kinase and downstream pathways.
Jing Zhang +8 more
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Compartmentalization of DNA Damage Response between Heterochromatin and Euchromatin Is Mediated by Distinct H2A Histone Variants [PDF]
Current Biology, 2017 Zdravko J. Lorković +6 more
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Fiber-Like Organization as a Basic Principle for Euchromatin Higher-Order Structure
Frontiers in Cell and Developmental Biology, 2022 A detailed understanding of the principles of the structural organization of genetic material is of great importance for elucidating the mechanisms of differential regulation of genes in development.
Amir N. Zakirov +13 more
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The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways
Frontiers in Cell and Developmental Biology, 2022 DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired by two pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ), the choice of which is largely dependent on cell cycle phase and the ...
Zulong Chen, Jessica K. Tyler
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A physical model of euchromatin organization. [PDF]
Proc Natl Acad Sci U S ALequieu J.
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Insect molecular biology (Print), 2023 Satellite DNAs (satDNAs) are highly repeated tandem sequences primarily located in heterochromatin, although their occurrence in euchromatin has been reported. Here, our aim was to advance the understanding of satDNA and multiple sex chromosome evolution
D. C. Cabral-de-Mello +5 more
semanticscholar +1 more source
Euchromatin and Pericentromeric Heterochromatin: Comparative Composition in the Tomato Genome [PDF]
Genetics, 2006 Abstract Eleven sequenced BACs were annotated and localized via FISH to tomato pachytene chromosomes providing the first global insights into the compositional differences of euchromatin and pericentromeric heterochromatin in this model dicot species.
Ying Wang +5 more
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The histone deubiquitinase OTLD1 targets euchromatin to regulate plant growth [PDF]
Science Signaling, 2016 Ido Keren, Vitaly Citovsky
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Nature Communications, 2022 The chromatin remodeller ATRX interacts with the histone chaperone DAXX to deposit the histone variant H3.3 at sites of nucleosome turnover. ATRX is known to bind repetitive, heterochromatic regions of the genome including telomeres, ribosomal DNA and ...
Julia Truch +13 more
semanticscholar +1 more source