Results 31 to 40 of about 15,818 (212)
European Journal of Entomology, 2014 The occurrence of transposable elements (TEs) is a ubiquitous characteristic of eukaryotic genomes, and these sequences are highly abundant in some species. Due to their large genomes, grasshoppers (Orthoptera) appear to be potentially good candidates in
Octavio M. PALACIOS-GIMENEZ +2 more
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You shall not pass! A Chromatin barrier story in plants
Frontiers in Plant Science, 2022 As in other eukaryotes, the plant genome is functionally organized in two mutually exclusive chromatin fractions, a gene-rich and transcriptionally active euchromatin, and a gene-poor, repeat-rich, and transcriptionally silent heterochromatin.
Florent Velay +3 more
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Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes [PDF]
Cancers, 2018 Chromosomal translocations drive the development of many hematological and some solid cancers. Several factors have been identified to explain the non-random occurrence of translocation breakpoints in the genome. These include chromatin density, gene density and CCCTC-binding factor (CTCF)/cohesin binding site density.
Pascal H.G. Duijf +6 more
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TALEN outperforms Cas9 in editing heterochromatin target sites
Nature Communications, 2021 While Cas9 outperforms TALENs in euchromatin, it is less efficient in heterochromatic regions. Here the authors, using single-molecule imaging, show that Cas9 uses a less efficient search strategy compared to TALENs in these regions.
Surbhi Jain +12 more
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A maximum-entropy model to predict 3D structural ensembles of chromatins from pairwise distances: Applications to Interphase Chromosomes and Structural Variants [PDF]
, 2022 The principles that govern the organization of genomes, which are needed for a deeper understanding of how chromosomes are packaged and function in eukaryotic cells, could be deciphered if the three-dimensional (3D) structures are known. Recently, single-cell imaging experiments have determined the 3D coordinates of a number of loci in a chromosome ...
arxiv +1 more source
Molecular Oncology, 2018 Long interspersed nuclear element‐1 (LINE‐1 or L1) reactivation is linked to poor prognosis in non‐small‐cell lung carcinoma (NSCLC), but the molecular bases of this response remain largely unknown.
Pasano Bojang Jr., Kenneth S. Ramos
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Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2017 Heterochromatin contains a significant part of nuclear DNA. Little is known about the mechanisms that govern heterochromatic DNA stability. We show here that in the yeast Saccharomyces cerevisiae (i) DNA mismatch repair (MMR) is required for the ...
Basanta K Dahal +6 more
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A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types [PDF]
PLoS ONE 8(9): e73818, 2013 Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it. Histone proteins are implicated in the regulation of eukaryote genes and they carry numerous reversible post-translational modifications
arxiv +1 more source
The Ino80 complex prevents invasion of euchromatin into silent chromatin [PDF]
Genes & Development, 2015 Here we show that the Ino80 chromatin remodeling complex (Ino80C) directly prevents euchromatin from invading transcriptionally silent chromatin within intergenic regions and at the border of euchromatin and heterochromatin. Deletion of Ino80C subunits leads to increased H3K79 methylation and noncoding RNA polymerase II (Pol II) transcription centered ...
Xue, Yong +12 more
openaire +6 more sources
The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto +4 more
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