Results 41 to 50 of about 15,596 (174)
Cell nucleus elastography with the adjoint-based inverse solver [PDF]
Computer Methods and Programs in Biomedicine, In press, 2023 Background and Objectives: The mechanics of the nucleus depends on cellular structures and architecture, and impact a number of diseases. Nuclear mechanics is yet rather complex due to heterogeneous distribution of dense heterochromatin and loose euchromatin domains, giving rise to spatially variable stiffness properties.
arxiv
Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells
Advanced Science, EarlyView.Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang +20 more
wiley +1 more source
Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. [PDF]
PLoS Genetics, 2010 DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications.
Tae-Jin Lee +15 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu +5 more
wiley +1 more source
Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]
PLoS Pathogens, 2013 The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Zsolt Toth +6 more
doaj +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
Drosophila SETDB1 is required for chromosome 4 silencing. [PDF]
PLoS Genetics, 2007 Histone H3 lysine 9 (H3K9) methylation is associated with gene repression and heterochromatin formation. In Drosophila, SU(VAR)3-9 is responsible for H3K9 methylation mainly at pericentric heterochromatin.
Carole Seum +5 more
doaj +1 more source
Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators [PDF]
, 2011 Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions. The mechanistic basis for insulator activity and how it relates to enhancer action-at-a-distance remains unclear. Here we explore the idea
arxiv +1 more source
Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire
PROTEOMICS, EarlyView.ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley +1 more source
Epigenetic gene expression links heart failure to memory impairment
EMBO Molecular Medicine, 2021 In current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ‐centered approach is not always suitable.
Md Rezaul Islam +14 more
doaj +1 more source