Results 51 to 60 of about 33,370 (268)

Chromosomal mapping of two Mariner-like elements in the grasshopper Abracris flavolineata (Orthoptera: Acrididae) reveals enrichment in euchromatin

open access: yesEuropean Journal of Entomology, 2014
The occurrence of transposable elements (TEs) is a ubiquitous characteristic of eukaryotic genomes, and these sequences are highly abundant in some species. Due to their large genomes, grasshoppers (Orthoptera) appear to be potentially good candidates in
Octavio M. PALACIOS-GIMENEZ   +2 more
doaj   +1 more source

TALEN outperforms Cas9 in editing heterochromatin target sites

open access: yesNature Communications, 2021
While Cas9 outperforms TALENs in euchromatin, it is less efficient in heterochromatic regions. Here the authors, using single-molecule imaging, show that Cas9 uses a less efficient search strategy compared to TALENs in these regions.
Surbhi Jain   +12 more
doaj   +1 more source

Evolutionary History of Alpha Satellite DNA Repeats Dispersed within Human Genome Euchromatin

open access: yesGenome Biology and Evolution, 2020
Major human alpha satellite DNA repeats are preferentially assembled within (peri)centromeric regions but are also dispersed within euchromatin in the form of clustered or short single repeat arrays.
I. Feliciello   +4 more
semanticscholar   +1 more source

A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types [PDF]

open access: yes, 2013
Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it.
Jensen, Ole Nørregaard   +1 more
core   +4 more sources

Insulator-based loops mediate the spreading of H3K27me3 over distant micro-domains repressing euchromatin genes

open access: yesGenome Biology, 2020
Background Chromosomes are subdivided spatially to delimit long-range interactions into topologically associating domains (TADs). TADs are often flanked by chromatin insulators and transcription units that may participate in such demarcation. Remarkably,
Alexandre Heurteau   +6 more
semanticscholar   +1 more source

The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during Reactivation. [PDF]

open access: yes, 2018
The human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. We learned that the latent episome of the human Epstein-Barr virus (EBV) preferentially associates with gene-poor chromosomes ...
Fernandez, Samantha G   +7 more
core   +1 more source

Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation [PDF]

open access: yes, 2019
DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors.
Chereji, Razvan V.   +4 more
core   +1 more source

The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation [PDF]

open access: yes, 2016
Lamin A is a component of the nuclear matrix that also controls proliferation by largely unknown mechanisms. NF-Y is a ubiquitous protein involved in cell proliferation composed of three subunits (-YA -YB -YC) all required for the DNA ...
Alonzi, Tonino   +16 more
core   +2 more sources

Epigenetic reactivation of LINE‐1 retrotransposon disrupts NuRD corepressor functions and induces oncogenic transformation in human bronchial epithelial cells

open access: yesMolecular Oncology, 2018
Long interspersed nuclear element‐1 (LINE‐1 or L1) reactivation is linked to poor prognosis in non‐small‐cell lung carcinoma (NSCLC), but the molecular bases of this response remain largely unknown.
Pasano Bojang Jr., Kenneth S. Ramos
doaj   +1 more source

Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators [PDF]

open access: yes, 2011
Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions.
A. M. Sengupta   +39 more
core   +3 more sources

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