Results 51 to 60 of about 15,596 (174)
RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection
Molecular Ecology Resources, EarlyView.ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone +3 more
wiley +1 more source
Peptide AEDL alters chromatin conformation via histone binding
AIMS Biophysics, 2020 Eukaryotic DNA is tightly packed into chromatin, a DNA–protein structure that exists as transcriptionally permissive euchromatin or repressive heterochromatin. Post-translational modification of histones plays a key role in regulating chromatin dynamics.
Larisa I. Fedoreyeva +2 more
doaj +1 more source
Opposing Roles of FACT for Euchromatin and Heterochromatin in Yeast
Biomolecules, 2023 DNA is stored in the nucleus of a cell in a folded state; however, only the necessary genetic information is extracted from the required group of genes. The key to extracting genetic information is chromatin ambivalence.
Shinya Takahata, Yota Murakami
doaj +1 more source
Aging Cell, EarlyView.Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu +4 more
wiley +1 more source
Chromatin associations in Arabidopsis interphase nuclei
Frontiers in Genetics, 2014 The arrangement of chromatin within interphase nuclei seems to be caused by topological constraints and related to gene expression depending on tissue and developmental stage.
Veit eSchubert +2 more
doaj +1 more source
Polymer Modelling Predicts Chromosome Reorganisation in Senescence [PDF]
Cell Reports 28, 3212 (2019), 2020 Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy and mass spectrometry to dissect the roles played by heterochromatin- and lamina-mediated interactions in nuclear organisation.
arxiv
Developmental Medicine &Child Neurology, EarlyView.Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale +14 more
wiley +1 more source
Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos. [PDF]
PLoS Genetics, 2011 Upon fertilization, reprogramming of gene expression is required for embryo development. This step is marked by DNA demethylation and changes in histone variant composition.
Tomohiko Akiyama +3 more
doaj +1 more source
The FEBS Journal, EarlyView.Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura +8 more
wiley +1 more source
Nature Communications, 2019 Eukaryotic genomes are segregated into euchromatin and heterochromatin. Here the authors show that heterochromatin establishment during zebrafish embryo development is controlled by zygotic transcription of miR-430 and subsequent degradation of maternal ...
Kathrin Laue +4 more
doaj +1 more source