Results 51 to 60 of about 16,530 (161)
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, Volume 13, Issue 6, 30 January 2026.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos. [PDF]
PLoS Genetics, 2011 Upon fertilization, reprogramming of gene expression is required for embryo development. This step is marked by DNA demethylation and changes in histone variant composition.
Tomohiko Akiyama +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim +10 more
wiley +1 more source
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication
BioEssays, Volume 48, Issue 1, January 2026.Origin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Victoria Frisbie, Franziska Bleichert
wiley +1 more source
Frontiers in Cellular Neuroscience, 2014 We investigated neuronal self-defense mechanisms in a murine model of amyotrophic lateral sclerosis (ALS), the transgenic hSOD1G93A, during both the asymptomatic and symptomatic stages.
Javier eRiancho +5 more
doaj +1 more source
BioEssays, Volume 48, Issue 1, January 2026.We hypothesize that the TPL corepressor (and likely others) acts as a transcriptional linchpin, stabilizing a state similar yet distinct from the metazoan paused state by recruiting Mediator and other components needed to initiate and coordinate transcriptional bursts across multiple genes.
Alexander R. Leydon +1 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.This study aimed to evaluate the in ovo injection of nettle extract, mushroom extract and their mixture as natural anti‐aromatase on sex reversal, histological changes in ovaries and testes and carcass characteristics of Ross 308 broiler chickens. Sex differentiation in avian species A completely randomized block design used to allocate 500 fertilized ...
Ali Akbari‐Balajorshari +3 more
wiley +1 more source
Mg 2+ -dependent ATPase activity in triatomine salivary glands (Heteroptera, Triatominae)
Iheringia: Série Zoologia, 2017 Mg2+-ATPase activity was detected in the three salivary glands of adult triatomines, males and females, of Triatoma infestans (Klug, 1834) and Panstrongylus megistus (Burmeister, 1835) (Heteroptera, Triatominae). A predominance of binucleated cells in D1
Ana C. B. M. Anhê +1 more
doaj +1 more source
Pathology International, Volume 76, Issue 1, January 2026.SET domain containing 5 (SETD5), a chromatin regulator involved in adipocytic differentiation. However, its immunohistochemical expression and prognostic significance in liposarcoma remain unclear. In our study, SETD5 expression was markedly elevated in the dedifferentiated component of dedifferentiated liposarcoma compared to the well‐differentiated ...
Makoto Abe +10 more
wiley +1 more source
Bio-Protocol, 2016 Barley is a diploid inbreeding crop with a genome of 5 GB organized into seven chromosomes. The relatively low chromosome number and their large size make barley an excellent model for chromosome cytogenetic studies of large genome cereal crops ...
Isabelle Colas +2 more
doaj +1 more source