Results 61 to 70 of about 19,515 (233)

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin

bioRxiv, 2019
Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Y. C. G. Lee, Yuki Ogiyama, Nuno M. C. Martins, Brian J. Beliveau, David Acevedo, C.-ting Wu, Giacomo Cavalli, G. Karpen   +7 more
semanticscholar   +1 more source

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

Advanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee   +15 more
wiley   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomes [PDF]

Genome Biology, 2004
Abstract Background Human centromere regions are characterized by the presence of alpha-satellite DNA, replication late in S phase and a heterochromatic appearance. Recent models propose that the centromere is organized into conserved chromatin domains in which chromatin containing CenH3 (centromere ...
Jennifer Babcock, M. Katharine Rudd, M. Katharine Rudd, Brian P. Chadwick, Brian P. Chadwick, Huntington F. Willard, Huntington F. Willard, Brenda R. Grimes, Brenda R. Grimes   +8 more
openaire   +3 more sources

Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis

Genome Biology, 2019
Background Chromatin provides a tunable platform for gene expression control. Besides the well-studied core nucleosome, H1 linker histones are abundant chromatin components with intrinsic potential to influence chromatin function. Well studied in animals,
Kinga Rutowicz, Maciej Lirski, Benoît Mermaz, Gianluca Teano, Jasmin Schubert, Imen Mestiri, Magdalena A. Kroteń, Tohnyui Ndinyanka Fabrice, Simon Fritz, Stefan Grob, Christoph Ringli, Lusik Cherkezyan, Fredy Barneche, Andrzej Jerzmanowski, Célia Baroux   +14 more
doaj   +1 more source

Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. [PDF]

PLoS Genetics, 2010
DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications.
Tae-Jin Lee, Pete E Pascuzzi, Sharon B Settlage, Randall W Shultz, Milos Tanurdzic, Pablo D Rabinowicz, Margit Menges, Ping Zheng, Dorrie Main, James A H Murray, Bryon Sosinski, George C Allen, Robert A Martienssen, Linda Hanley-Bowdoin, Matthew W Vaughn, William F Thompson   +15 more
doaj   +1 more source

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

Genes & Development, 2016
Janssen et al. developed an in vivo single double-strand break (DSB) system for both heterochromatic and euchromatic loci in Drosophila melanogaster.
A. Janssen, Gregory A. Breuer, E. K. Brinkman, Annelot I van der Meulen, Sean V Borden, B. van Steensel, R. Bindra, Jeannine R. LaRocque, G. Karpen   +8 more
semanticscholar   +1 more source

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non‐heading Chinese Cabbage

Advanced Science, EarlyView.
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren   +10 more
wiley   +1 more source

Drosophila SETDB1 is required for chromosome 4 silencing. [PDF]

PLoS Genetics, 2007
Histone H3 lysine 9 (H3K9) methylation is associated with gene repression and heterochromatin formation. In Drosophila, SU(VAR)3-9 is responsible for H3K9 methylation mainly at pericentric heterochromatin.
Carole Seum, Emanuela Reo, Hongzhuang Peng, Frank J Rauscher, Pierre Spierer, Séverine Bontron   +5 more
doaj   +1 more source

Homeostasis of DNA Hemi‐Methylation in Arabidopsis through Methylation Maintenance, DNA Replication, and Nucleosome Positioning Mechanisms

Advanced Science, EarlyView.
In Arabidopsis, the homeostasis of full‐ and hemi‐methylation is mainly regulated by maintenance methylation. The maintenance methylation at hemi‐methylated dyads is highly efficient but the efficiency differs at euchromatic or heterochromatic regions. Nucleosomes impair the hemi‐ to full‐methylation transition. Lagged methylation maintenance after DNA
Hengye Chen, Chenhuan Xu
wiley   +1 more source