Results 61 to 70 of about 16,530 (161)

Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain

Communications Biology
Drosophila P75 (dP75), a homolog of the human LEDGF/p75, is crucial for oogenesis by recruiting the histone kinase Jil-1 to euchromatin and impeding H3K9me2 spreading.
Zhaohui Jin, Zhe Meng, Yanchao Liu, Chongyang Li, Xuedi Zhang, Yue Yin, Guanjun Gao, Kun Dou, Ying Huang   +8 more
doaj   +1 more source

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Stem Cell Reports, 2018
Summary: Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. However, the molecular mechanism controlling the uneven distribution and its biological significance remain to be elucidated.
Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi, Katsuhiko Shirahige, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana   +13 more
doaj   +1 more source

Subcellular organization of UBE3A in human cerebral cortex

Molecular Autism, 2018
Background Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Alain C. Burette, Matthew C. Judson, Alissa N. Li, Edward F. Chang, William W. Seeley, Benjamin D. Philpot, Richard J. Weinberg   +6 more
doaj   +1 more source

Homologues of potato chromosome 5 show variable collinearity in the euchromatin, but dramatic absence of sequence similarity in the pericentromeric heterochromatin [PDF]

, 2015
J.M. de Boer, Erwin Datema, Xiaomin Tang, Theo Borm, Erin Bakker, Herman J. van Eck, Roeland C. H. J. van Ham, Hans de Jong, Richard G. F. Visser, C. Bachem   +9 more
openalex   +1 more source

Alternative end-joining results in smaller deletions in heterochromatin relative to euchromatin

, 2023
Jacob M. Miller, Sydney Prange, Huanding Ji, Alesandra R. Rau, Varandt Y. Khodaverdian, Xiao Li, Avi Patel, Nadejda Butova, Avery Lutter, Helen Chung, Chiara Merigliano, Chetan C. Rawal, Terrence Hanscom, Mitch McVey, Irene Chiolo   +14 more
openalex   +1 more source

Molecular Targets of Chromatin Repressive Mark H3K9me3 in Primate Progenitor Cells within Adult Neurogenic Niches

Frontiers in Genetics, 2014
Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the ...
Michael R Foret, Richard S Sandstrom, Christopher T Rhodes, Yufeng eWang, Mitchel S Berger, Chin-Hsing Annie eLin, Chin-Hsing Annie eLin   +6 more
doaj   +1 more source

Transcription organizes euchromatin similar to an active microemulsion [PDF]

, 2017
Lennart Hilbert, Yuko Sato, Hiroshi Kimurâ, Frank Jülicher, Alf Honigmann, Vasily Zaburdaev, Nadine L. Vastenhouw   +6 more
openalex   +1 more source

Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair

Nature Communications
DNA double-strand breaks (DSBs) must be properly repaired within diverse chromatin domains to maintain genome stability. Whereas euchromatin has an open structure and is associated with transcription, facultative heterochromatin is essential to silence ...
Marieke R. Wensveen, Aditya A. Dixit, Robin van Schendel, Apfrida Kendek, Jan-Paul Lambooij, Marcel Tijsterman, Serafin U. Colmenares, Aniek Janssen   +7 more
doaj   +1 more source

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar, Jaroslaw Paturej, Edward J. Banigan, Aykut Erbaş   +3 more
doaj   +1 more source

Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions

BMC Genomics, 2012
Background The organization of higher order chromatin is an emerging epigenetic mechanism for understanding development and disease. We and others have previously observed dynamic changes during differentiation and oncogenesis in large heterochromatin ...
Wen Bo, Wu Hao, Loh Yuin-Han, Briem Eirikur, Daley George Q, Feinberg Andrew P   +5 more
doaj   +1 more source