Results 71 to 80 of about 15,596 (174)

In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]

open access: yesopen autoimmunty journal 1 (2009) 27-32, 2009
FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD, the nuclear FADD was shown to protect cells from apoptosis.
arxiv  

Investigating Neotenic and Metamorphic Axolotl Brain Complexity: A Stereological and Immunohistochemical Perspective

open access: yesJournal of Comparative Neurology, Volume 533, Issue 3, March 2025.
In the telencephalon, apical specializations such as cilia, primary cilia, and microvilli with varying morphologies were observed. Goblet‐like cells, arranged in a single row along the ventricular wall, contained secretory vesicles in their apical regions. Light microscopy demonstrated that these secretory vesicles had a carbohydrate‐rich structure, as
Arife Ahsen Kaplan   +3 more
wiley   +1 more source

Cytology and Microscopy: Immunolocalization of Covalently Modified Histone Marks on Barley Mitotic Chromosomes

open access: yesBio-Protocol, 2016
Barley is a diploid inbreeding crop with a genome of 5 GB organized into seven chromosomes. The relatively low chromosome number and their large size make barley an excellent model for chromosome cytogenetic studies of large genome cereal crops ...
Isabelle Colas   +2 more
doaj   +1 more source

Molecular Targets of Chromatin Repressive Mark H3K9me3 in Primate Progenitor Cells within Adult Neurogenic Niches

open access: yesFrontiers in Genetics, 2014
Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the ...
Michael R Foret   +6 more
doaj   +1 more source

Subcellular organization of UBE3A in human cerebral cortex

open access: yesMolecular Autism, 2018
Background Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Alain C. Burette   +6 more
doaj   +1 more source

Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain

open access: yesCommunications Biology
Drosophila P75 (dP75), a homolog of the human LEDGF/p75, is crucial for oogenesis by recruiting the histone kinase Jil-1 to euchromatin and impeding H3K9me2 spreading.
Zhaohui Jin   +8 more
doaj   +1 more source

Active Hydrodynamic Theory of Euchromatin and Heterochromatin [PDF]

open access: yesarXiv
The genome contains genetic information essential for cell's life. The genome's spatial organization inside the cell nucleus is critical for its proper function including gene regulation. The two major genomic compartments -- euchromatin and heterochromatin -- contain largely transcriptionally active and silenced genes, respectively, and exhibit ...
arxiv  

Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions

open access: yesBMC Genomics, 2012
Background The organization of higher order chromatin is an emerging epigenetic mechanism for understanding development and disease. We and others have previously observed dynamic changes during differentiation and oncogenesis in large heterochromatin ...
Wen Bo   +5 more
doaj   +1 more source

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