Results 71 to 80 of about 19,515 (233)

Epigenetic gene expression links heart failure to memory impairment

EMBO Molecular Medicine, 2021
In current clinical practice, care of diseased patients is often restricted to separated disciplines. However, such an organ‐centered approach is not always suitable.
Md Rezaul Islam, Dawid Lbik, M Sadman Sakib, Raoul Maximilian Hofmann, Tea Berulava, Martí Jiménez Mausbach, Julia Cha, Maria Goldberg, Elerdashvili Vakhtang, Christian Schiffmann, Anke Zieseniss, Dörthe Magdalena Katschinski, Farahnaz Sananbenesi, Karl Toischer, Andre Fischer   +14 more
doaj   +1 more source

Cistanche tubulosa improves peripheral neuropathy in MPTP‐induced PD mice based on regulation of m6A methylation

Animal Models and Experimental Medicine, EarlyView.
At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li, Wei Jia, Junhua Hu, Borui Zhang, Xinxin Qi, Jianhua Yang, Xinling Yang   +6 more
wiley   +1 more source

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]

PLoS Pathogens, 2013
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Zsolt Toth, Kevin Brulois, Hye-Ra Lee, Yoshihiro Izumiya, Clifford Tepper, Hsing-Jien Kung, Jae U Jung   +6 more
doaj   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Euchromatin histone methyltransferase 1 regulates cortical neuronal network development

Scientific Reports, 2016
Heterozygous mutations or deletions in the human Euchromatin histone methyltransferase 1 (EHMT1) gene cause Kleefstra syndrome, a neurodevelopmental disorder that is characterized by autistic-like features and severe intellectual disability (ID ...
Marijn Bart Martens, M. Frega, Jessica Classen, L. Epping, E. Bijvank, M. Benevento, H. van Bokhoven, P. Tiesinga, D. Schubert, N. Nadif Kasri   +9 more
semanticscholar   +1 more source

Peptide AEDL alters chromatin conformation via histone binding

AIMS Biophysics, 2020
Eukaryotic DNA is tightly packed into chromatin, a DNA–protein structure that exists as transcriptionally permissive euchromatin or repressive heterochromatin. Post-translational modification of histones plays a key role in regulating chromatin dynamics.
Larisa I. Fedoreyeva, Boris F. Vanyushin, Ekaterina N. Baranova   +2 more
doaj   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, EarlyView.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

Confining euchromatin/heterochromatin territory: jumonji crosses the line [PDF]

Genes & Development, 2010
Heterochromatin is typically highly condensed, gene-poor, and transcriptionally silent, whereas euchromatin is less condensed, gene-rich, and more accessible to transcription. Besides acting as a graveyard for selfish mobile DNA repeats, heterochromatin contributes to important biological functions, such as chromosome segregation during cell division ...
openaire   +3 more sources

RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection

Molecular Ecology Resources, EarlyView.
ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone, Rob Elphinstone, Marco Todesco, Loren H. Rieseberg   +3 more
wiley   +1 more source