Results 81 to 90 of about 33,370 (268)
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang+5 more
wiley +1 more source
Assembly and characterization of heterochromatin and euchromatin on human artificial chromosomes [PDF]
Abstract Background Human centromere regions are characterized by the presence of alpha-satellite DNA, replication late in S phase and a heterochromatic appearance. Recent models propose that the centromere is organized into conserved chromatin domains in which chromatin containing CenH3 (centromere ...
Jennifer Babcock+8 more
openaire +3 more sources
Somatic Pairing in Drosophila virilis Mitosis [PDF]
In neuroblast cells homologous chromosomes tend to pair during prophase of mitosis. Heterochromatic elements of homologous chromosomes are widely separated in very early prophase, at which time the euchromatin is poorly stained.
Guest, William C.
core +2 more sources
Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization [PDF]
A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of ...
Anna Jauch+22 more
core +1 more source
Background Chromatin provides a tunable platform for gene expression control. Besides the well-studied core nucleosome, H1 linker histones are abundant chromatin components with intrinsic potential to influence chromatin function. Well studied in animals,
Kinga Rutowicz+14 more
doaj +1 more source
Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. [PDF]
DNA replication programs have been studied extensively in yeast and animal systems, where they have been shown to correlate with gene expression and certain epigenetic modifications.
Tae-Jin Lee+15 more
doaj +1 more source
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang+10 more
wiley +1 more source
Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]
FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during ...
Angus I. Lamond+52 more
core +4 more sources
Euchromatin histone methyltransferase 1 regulates cortical neuronal network development
Heterozygous mutations or deletions in the human Euchromatin histone methyltransferase 1 (EHMT1) gene cause Kleefstra syndrome, a neurodevelopmental disorder that is characterized by autistic-like features and severe intellectual disability (ID ...
Marijn Bart Martens+9 more
semanticscholar +1 more source
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi+8 more
wiley +1 more source