Results 81 to 90 of about 15,818 (212)
Lid2 Is Required for Coordinating H3K4 and H3K9 Methylation of Heterochromatin and Euchromatin [PDF]
Cell, 2008 In most eukaryotes, histone methylation patterns regulate chromatin architecture and function: methylation of histone H3 lysine-9 (H3K9) demarcates heterochromatin, whereas H3K4 methylation demarcates euchromatin. We show here that the S. pombe JmjC-domain protein Lid2 is a trimethyl H3K4 demethylase responsible for H3K4 hypomethylation in ...
Mikel Zaratiegui +6 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2014 We investigated neuronal self-defense mechanisms in a murine model of amyotrophic lateral sclerosis (ALS), the transgenic hSOD1G93A, during both the asymptomatic and symptomatic stages.
Javier eRiancho +5 more
doaj +1 more source
Epigenetic Histone Deacetylases Activity Assay in the Brain and Peripheral Organ Tissues
Current Protocols, Volume 5, Issue 6, June 2025.Abstract Histone deacetylases (HDACs) are crucial epigenetic regulators involved in the modulation of gene expression and are promising therapeutic targets for treating various diseases, including central nervous system disorders and cancer. HDAC inhibitors exhibit neuroprotective, antiepileptogenic, and antidepressant properties in animal models ...
Doodipala Samba Reddy +5 more
wiley +1 more source
Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy
MedComm – Oncology, Volume 4, Issue 2, June 2025.Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang +4 more
wiley +1 more source
Mg 2+ -dependent ATPase activity in triatomine salivary glands (Heteroptera, Triatominae)
Iheringia: Série Zoologia, 2017 Mg2+-ATPase activity was detected in the three salivary glands of adult triatomines, males and females, of Triatoma infestans (Klug, 1834) and Panstrongylus megistus (Burmeister, 1835) (Heteroptera, Triatominae). A predominance of binucleated cells in D1
Ana C. B. M. Anhê +1 more
doaj +1 more source
Landscape of rare‐allele variants in cultivated and wild soybean genomes
The Plant Genome, Volume 18, Issue 2, June 2025.Abstract Rare‐allele variants are important for crop improvement because they can be linked to important traits. However, genome‐wide distribution and annotation of rare‐allele variants have not been reported. We analyzed sequencing data from 1556 soybean accessions and found 6,533,419 rare‐allele variants in Glycine max and 941,274 in Glycine soja ...
Zhi Liu +9 more
wiley +1 more source
In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]
open autoimmunty journal 1 (2009) 27-32, 2009 FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD, the nuclear FADD was shown to protect cells from apoptosis.
arxiv
Aging Cell, Volume 24, Issue 6, June 2025.Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu +4 more
wiley +1 more source
Bio-Protocol, 2016 Barley is a diploid inbreeding crop with a genome of 5 GB organized into seven chromosomes. The relatively low chromosome number and their large size make barley an excellent model for chromosome cytogenetic studies of large genome cereal crops ...
Isabelle Colas +2 more
doaj +1 more source
Frontiers in Genetics, 2014 Histone 3 Lysine 9 (H3K9) methylation is known to be associated with pericentric heterochromatin and important in genomic stability. In this study, we show that trimethylation at H3K9 (H3K9me3) is enriched in an adult neural stem cell niche- the ...
Michael R Foret +6 more
doaj +1 more source