Results 121 to 130 of about 443,960 (348)

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources

BMC Bioinformatics, 2006
BackgroundIn order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons and EST and protein alignments.
M. Stanke, Oliver Schöffmann, B. Morgenstern, S. Waack   +3 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

The Vestfold Hills are alive: characterising microbial and environmental dynamics in Old Wallow, eastern Antarctica

Frontiers in Microbiology
Old Wallow is an underexplored, hyper-arid coastal desert in Antarctica’s Vestfold Hills. Situated near an elephant seal wallow, we examined how stochastic nutrient inputs from the seal wallow affect soil communities amid environmental changes along a ...
Devan S. Chelliah, Angelique E. Ray, Eden Zhang, Eden Zhang, Aleks Terauds, Belinda C. Ferrari, Belinda C. Ferrari   +6 more
doaj   +1 more source

Microbial Eukaryotes: a Missing Link in Gut Microbiome Studies

mSystems, 2018
Human-associated microbial communities include prokaryotic and eukaryotic organisms across high-level clades of the tree of life. While advances in high-throughput sequencing technology allow for the study of diverse lineages, the vast majority of ...
Isabelle Laforest-Lapointe, Marie-Claire Arrieta   +1 more
doaj   +1 more source

Origins of DNA replication in eukaryotes.

Molecules and Cells, 2023
Yixin Hu, B. Stillman
semanticscholar   +1 more source

Diversification of giant and large eukaryotic dsDNA viruses predated the origin of modern eukaryotes

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The viruses from the Nucleo-Cytoplasmic Large DNA Virus (NCLDV) assemblage regularly draw the attention of the scientific community for their surprising features, from the gigantism of some viruses’ particles to their genome content.
Julien Guglielmini, A. C. Woo, M. Krupovic, P. Forterre, Morgan Gaia   +4 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Expanded diversity of Asgard archaea and their relationships with eukaryotes

Nature, 2021
Yang Liu, K. Makarova, Wen-Cong Huang, Y. Wolf, A. Nikolskaya, Xinxu Zhang, Mingwei Cai, Cuijing Zhang, Wei Xu, Zhuhua Luo, Lei Cheng, E. Koonin, Meng Li   +12 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source