Results 161 to 170 of about 443,960 (348)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Environmental DNA reveals temporal variation in mesophotic reefs of the Humboldt upwelling ecosystems of central Chile: Toward a baseline for biodiversity monitoring of unexplored marine habitats

Ecology and Evolution
Temperate mesophotic reef ecosystems (TMREs) are among the least known marine habitats. Information on their diversity and ecology is geographically and temporally scarce, especially in highly productive large upwelling ecosystems.
Pablo Saenz‐Agudelo, Paula Ramirez, Ricardo Beldade, Ana N. Campoy, Vladimir Garmendia, Francesca V. Search, Miriam Fernández, Evie A. Wieters, Sergio A. Navarrete, Mauricio F. Landaeta, Alejandro Pérez‐Matus   +10 more
doaj   +1 more source

Immunomodulatory peptides: new therapeutic horizons for emerging and re-emerging infectious diseases

Frontiers in Microbiology
The emergence and re-emergence of multi-drug-resistant (MDR) infectious diseases have once again posed a significant global health challenge, largely attributed to the development of bacterial resistance to conventional anti-microbial treatments.
Debolina Chatterjee, Karthikeyan Sivashanmugam   +1 more
doaj   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Autophagy, 2008
D. Klionsky, H. Abeliovich, P. Agostinis, D. Agrawal, G. Aliev, D. Askew, M. Baba, E. Baehrecke, B. Bahr, A. Ballabio, B. Bamber, D. Bassham, E. Bergamini, Xiaoning Bi, M. Biard-Piechaczyk, J. Blum, D. Bredesen, J. Brodsky, J. Brumell, U. Brunk, W. Bursch, N. Camougrand, E. Cebollero, F. Cecconi, Yingyu Chen, L. Chin, A. Choi, C. Chu, Jongkyeong Chung, P. Clarke, R. Clark, S. Clarke, C. Clavé, J. Cleveland, P. Codogno, M. Colombo, A. Coto-Montes, J. Cregg, A. Cuervo, Jayanta Debnath, F. Demarchi, P. Dennis, P. Dennis, V. Deretic, R. Devenish, F. Di Sano, J. Dice, M. Difiglia, S. Dinesh-Kumar, C. Distelhorst, M. Djavaheri-Mergny, F. Dorsey, W. Dröge, M. Dron, W. Dunn, M. Duszenko, N. Eissa, Z. Elazar, A. Esclatine, E. Eskelinen, L. Fésüs, K. Finley, J. M. Fuentes, J. Fueyo, K. Fujisaki, B. Galliot, F. Gao, D. Gewirtz, S. Gibson, A. Gohla, A. Goldberg, R. Gonzalez, Cristina González-Estévez, S. Gorski, R. Gottlieb, D. Häussinger, You-Wen He, K. Heidenreich, Joseph A. Hill, M. Høyer-Hansen, Xun Hu, Wei‐Pang Huang, A. Iwasaki, M. Jäättelä, W. Jackson, Xuejun Jiang, Shengkan Jin, T. Johansen, Jae U. Jung, M. Kadowaki, Chanhee Kang, A. Kelekar, D. Kessel, J. Kiel, Hong-pyo Kim, A. Kimchi, T. Kinsella, K. Kiselyov, K. Kitamoto, E. Knecht, M. Komatsu, E. Kominami, S. Kondo, A. Kovács, G. Kroemer, C. Kuan, Rakesh Kumar, M. Kundu, J. Landry, M. Laporte, W. Le, H. Lei, M. Lenardo, B. Levine, A. Lieberman, K. Lim, F. Lin, Willisa Liou, Leroy F. Liu, G. Lopez-Berestein, C. López-Otín, Bo Lu, K. Macleod, W. Malorni, W. Martinet, K. Matsuoka, J. Mautner, A. Meijer, A. Meléndez, P. Michels, G. Miotto, W. Mistiaen, N. Mizushima, B. Mograbi, Iryna Monastyrska, Michael Moore, P. Moreira, Y. Moriyasu, T. Motyl, C. Münz, Leon O. Murphy, Naweed I. Naqvi, T. P. Neufeld, I. Nishino, R. Nixon, T. Noda, B. Nürnberg, Michinaga Ogawa, N. Oleinick, L. J. Olsen, B. Ozpolat, S. Paglin, Glen E. Palmer, I. Papassideri, M. Parkes, D. Perlmutter, George Perry, M. Piacentini, R. Pinkas-Kramarski, M. Prescott, T. Proikas-Cezanne, N. Raben, A. Rami, F. Reggiori, B. Rohrer, D. Rubinsztein, K. Ryan, J. Sadoshima, H. Sakagami, Y. Sakai, M. Sandri, C. Sasakawa, M. Sass, C. Schneider, P. Seglen, O. Seleverstov, J. Settleman, J. Shacka, I. Shapiro, A. Sibirny, E. Silva-Zacarin, H. Simon, C. Simone, A. Simonsen, Mark A. Smith, K. Spanel‐borowski, V. Srinivas, Meredith A. Steeves, H. Stenmark, P. E. Stromhaug, C. Subauste, S. Sugimoto, D. Sulzer, Toshihiko Suzuki, M. Swanson, I. Tabas, F. Takeshita, N. Talbot, Z. Tallóczy, Keiji Tanaka, Kozo Tanaka, I. Tanida, G. Taylor, J. Taylor, A. Terman, Gianluca Tettamanti, C. Thompson, M. Thumm, A. Tolkovsky, S. Tooze, R. Truant, L. Tumanovska, Y. Uchiyama, T. Ueno, Néstor L Uzcátegui, I. J. van der Klei, E. Vaquero, T. Vellai, Michael W Vogel, Hong-Gang Wang, P. Webster, J. Wiley, Z. Xi, G. Xiao, J. Yahalom, Jin-Ming Yang, G. Yap, Xiao-Ming Yin, T. Yoshimori, Li Yu, Zhenyu Yue, M. Yuzaki, O. Zabirnyk, Xiaoxiang Zheng, Xiongwei Zhu, R. Deter   +235 more
semanticscholar   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

The New Tree of Eukaryotes.

Trends in Ecology & Evolution, 2019
Fabien Burki, A. Roger, Matthew W. Brown, A. Simpson   +3 more
semanticscholar   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source