Advanced Science, EarlyView.This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao +10 more
wiley +1 more source
Giant virus genomes are unlikely to be reservoirs of antibiotic resistance genes. [PDF]
Nat CommunBarth ZK.
europepmc +1 more source
Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, EarlyView.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Protein tandem repeats that produce frameshifts can generate new structural states and functions. [PDF]
FEBS JOsmanli Z +8 more
europepmc +1 more source
Protists with Uncertain Phylogenetic Affiliations for Resolving the Deep Tree of Eukaryotes. [PDF]
MicroorganismsYazaki E, Shiratori T, Inagaki Y.
europepmc +1 more source
Phylogeny-aware Simulations Suggest a Low Impact of Unsampled Lineages in the Inference of Gene Flow During Eukaryogenesis. [PDF]
Genome Biol EvolBernabeu M +2 more
europepmc +1 more source
Phylogenomic Analysis of Deep-Branching Telonemid. [PDF]
Genome Biol EvolBjornson S +3 more
europepmc +1 more source
Rethinking large-scale phylogenomics with EukPhylo v.1.0, a flexible toolkit to enable phylogeny-informed data curation and analyses of diverse eukaryotic lineages. [PDF]
mBioKatz LA +4 more
europepmc +1 more source
Evolutionary analysis of Trehalose breakdown pathways
Ganesh Muthu G +2 more
europepmc +1 more source