Results 41 to 50 of about 443,960 (348)
Frontiers in Plant ScienceThe histidine biosynthetic pathway (HBP) is targeted for herbicide design with preliminary success only regarding imidazole-glycerol phosphate dehydratase (IGPD, EC 4.2.1.19), or HISN5, as referred to in plants. HISN5 catalyzes the sixth step of the HBP,
Wojciech Witek +3 more
doaj +1 more source
Ubiquitin Signaling: Extreme Conservation as a Source of Diversity
Cells, 2014 Around 2 × 103–2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained in its proteome the same ...
Alice Zuin, Marta Isasa, Bernat Crosas
doaj +1 more source
Nanoencapsulated Curcumin: Enhanced Efficacy in Reversing Memory Loss in An Alzheimer Disease Model
Brain SciencesInvestigating new drugs or formulations that target Alzheimer disease (AD) is critical for advancing therapeutic interventions. Therefore, this study aimed to assess the effectiveness of nanoencapsulated curcumin (NC Curc) in alleviating memory ...
Anne Suély Pinto Savall +7 more
doaj +1 more source
Frontiers in NeurologyAtaxia-telangiectasia (A-T) is an autosomal recessive primary immunodeficiency disorder (PID) caused by biallelic mutations occurring in the serine/threonine protein kinase (ATM) gene.
Nihel Ammous-Boukhris +7 more
doaj +1 more source
Rumen Protozoa Play a Significant Role in Fungal Predation and Plant Carbohydrate Breakdown
Frontiers in Microbiology, 2020 The rumen protozoa, alongside fungi, comprise the eukaryotic portion of the rumen microbiome. Rumen protozoa may account for up to 50% of biomass, yet their role in this ecosystem remains unclear.
Cate L. Williams +5 more
doaj +1 more source
Mitochondrial Adaptations Underlying Tetraploidization in Human Cancer, Fungal, and Yeast Models
BiologyWhole-genome duplication, or tetraploidization, occurs in cells, tissues, or entire organisms. In human cancers, tetraploidization promotes aneuploidy and genomic instability, accelerating tumor progression, metastasis, and drug resistance.
Mohamed Jemaà +4 more
doaj +1 more source
Annual Review of BiochemistryMicroproteins are polypeptides of 100–150 amino acids or fewer that have not been annotated by genome annotation consortia, given their small size and other noncanonical properties. Translated microproteins are now known to number in the thousands in the human genome, to function in critical cellular and physiological processes, and to be dysregulated ...
Nadiya, Jaunbocus +3 more
openaire +2 more sources
Acidocalcisomes of eukaryotes [PDF]
Current Opinion in Cell Biology, 2016 Acidocalcisomes are organelles rich in polyphosphate and cations and acidified by proton pumps. Although they have also been described in prokaryotes they have been better characterized in unicellular and multicellular eukaryotes. Eukaryotic acidocalcisomes belong to the group of lysosome-related organelles.
Roberto Docampo, Guozhong Huang
openaire +2 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
HeliyonObjective: The present work aims to optimize fermentation parameters for the simultaneous production of eco-enzymes: proteases, amylases, and endoglucanases from the same fungus Stachybotrys microspora, and to evaluate their stability in free form and ...
Ines Ben Hmad, Ali Gargouri
doaj +1 more source