Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
The effect of mutational robustness on the evolvability of multicellular organisms and eukaryotic cells. [PDF]
J Evol Biol, 2023 Jiang P, Kreitman M, Reinitz J.
europepmc +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
RECOMBINANT EUKARYOTIC CELLS STABLY EXPRESSING (SID-1) PROTEINS FOR HIGH THROUGHPUT GENE SCREENING [PDF]
, 2008 This invention provides a eukaryotic cell that stably expresses exogenous, ectopic SID-1 to confer enhanced polynucleotide, e.g. siRNA or dsRNA, uptake. Thus, in one aspect, this invention provides a eukaryotic cell which stably expresses exogenous SID-1
core
Ensemble heterogeneity mimics ageing for endosomal dynamics within eukaryotic cells. [PDF]
Sci Rep, 2023 Korabel N +5 more
europepmc +1 more source
A circuit for secretion-coupled cellular autonomy in multicellular eukaryotic cells. [PDF]
Mol Syst Biol, 2023 Qiao L +11 more
europepmc +1 more source
TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice
Advanced Science, EarlyView.This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo +22 more
wiley +1 more source
Lungs, Liposomes, Libraries, and Likely Interactions Between Phages and Eukaryotic Cells. [PDF]
Phage (New Rochelle), 2023 Clokie M, Sicheritz-Pontén T.
europepmc +1 more source
Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation
Advanced Science, EarlyView.Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi +9 more
wiley +1 more source