Results 241 to 250 of about 614,303 (330)
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
In-Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells. [PDF]
Broft P +7 more
europepmc +1 more source
A Wheel of Fortune: the eukaryotic cell cycle as a tetra-stable excitable system [PDF]
Calin-Mihai Dragoi
openalex +1 more source
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li +13 more
wiley +1 more source
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang +9 more
wiley +1 more source
Protocol for the establishment of a serine integrase-based platform for functional validation of genetic switch controllers in eukaryotic cells. [PDF]
de Oliveira MA +13 more
europepmc +1 more source
Where Does N-Formylmethionine Come from? What for? Where Is It Going? What is the origin of N-formylmethionine in eukaryotic cells? [PDF]
Lee CS, Kim D, Hwang CS.
europepmc +1 more source

