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Early events in eukaryotic DNA replication
Trends in Cell Biology, 1992Eukaryotic DNA replication is a tightly regulated process that occurs during a discrete period of the cell cycle known as S phase. Recent work in two different systems has identified key participants in this process and characterized many of the protein-protein interactions required for the establishment of functional replication complexes.
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EUKARYOTIC DNA REPLICATION: Anatomy of An Origin
Annual Review of Biochemistry, 1993PERSPECTIVE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 ORIGINS OF DNA REPLICATION IN SIMPLE GENOMES . . . . . . . . . . . . . . . 31 Functional and Genetic Origins Are Coincident . . . . . . . . . . . . . . . . . . . . .
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Replication of DNA in Eukaryotic Chromosomes
1987Studies of DNA replication in chromosomes first clearly revealed the compartments of the cell cycle and provided a means for measuring the parameters of the S-phase in the cell cycle. Radioisotopic labeling, especially with [3H]-thymidine, provided a specific label easily detected by autoradiography, as well as by liquid scintillation counting for ...
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Eukaryotic DNA polymerases in DNA replication and DNA repair
Chromosoma, 1998DNA polymerases carry out a large variety of synthetic transactions during DNA replication, DNA recombination and DNA repair. Substrates for DNA polymerases vary from single nucleotide gaps to kilobase size gaps and from relatively simple gapped structures to complex replication forks in which two strands need to be replicated simultaneously ...
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Initiation of eukaryotic DNA replication in vitro
BioEssays, 1988AbstractRecent advances in our understanding of the mechanism and regulation of eukaryotic DNA replication have been expedited by the use of cell‐free systems capable of initiation of DNA replication. The system capable of replicating plasmid DNAs containing the SV40 origin of DNA replication in vitro is a paradigm for studies on the replication of ...
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Historical Perspective of Eukaryotic DNA Replication
2017The replication of the genome of a eukaryotic cell is a complex process requiring the ordered assembly of multiprotein replisomes at many chromosomal sites. The process is strictly controlled during the cell cycle to ensure the complete and faithful transmission of genetic information to progeny cells.
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Eukaryotic DNA replication origins: many choices for appropriate answers
Nature Reviews Molecular Cell Biology, 2010Marcel Mechali
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