Results 61 to 70 of about 173,490 (195)

Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2. [PDF]

Proceedings of the National Academy of Sciences, 1978
Initiation factor 2 (eIF-2) is phosphorylated in vitro by two different cyclic nucleotide-independent protein kinases. As previously shown, a protein kinase activity that comigrates with the major casein kinase activity from rabbit reticulocytes phosphorylates eIF-2beta.
S M, Tahara, J A, Traugh, S B, Sharp, T S, Lundak, B, Safer, W C, Merrick   +5 more
openaire   +2 more sources

Nuclear respiratory factor 1 activation sites in genes encoding the gamma-subunit of ATP synthase, eukaryotic initiation factor 2 alpha, and tyrosine aminotransferase. Specific interaction of purified NRF-1 with multiple target genes.

Journal of Biological Chemistry, 1992
Transcription factor nuclear respiratory factor 1 (NRF-1) was originally identified as an activator of the cytochrome c gene and subsequently found to stimulate transcription through specific sites in other nuclear genes whose products function in the ...
Ching Man A Chau, M. J. Evans, R. Scarpulla   +2 more
semanticscholar   +1 more source

EFFECTS OF A SINGLE BOUT OF AEROBIC EXERCISE ON SKELETAL MUSCLE PROTEIN TURNOVER IN MICE

Journal of Men's Health, 2017
Background and Objective Aerobic exercise has a strong effect on skeletal muscle metabolism, in both males and females of all ages. However, the effect of a single bout of aerobic exercise on the regulation of protein balance remains unknown.
Yong-An Kim, Wi-Young So
doaj  

CRISPR/Cas9-mediated LMP1 knockout inhibits Epstein-Barr virus infection and nasopharyngeal carcinoma cell growth

Infectious Agents and Cancer, 2019
Background A strong association between Epstein-Barr virus (EBV) infection and nasopharyngeal carcinoma (NPC) has been widely recognized in recent decades.
Haifeng Huo, Guohua Hu
doaj   +1 more source

A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.

Journal of Biological Chemistry, 1983
Formation of the ternary complex Met-tRNAi X eukaryotic initiation factor (eIF) 2 X GTP from eIF-2 X GDP requires exchange of GDP for GTP. However, at physiological Mg2+ concentrations, GDP is released from eIF-2 exceedingly slowly (Clemens, M.J., Pain, V.M., Wong, S.T., and Henshaw, E.C. (1982) Nature (Lond.) 296, 93-95).
R, Panniers, E C, Henshaw
openaire   +2 more sources

Ribosome Targeting of PKR Is Mediated by Two Double-stranded RNA-binding Domains and Facilitates in Vivo Phosphorylation of Eukaryotic Initiation Factor-2*

Journal of Biological Chemistry, 1997
Protein kinase PKR is activated in mammalian cells during viral infection, leading to phosphorylation of the α subunit of eukaryotic initiation factor-2 (eIF-2α) and inhibition of protein synthesis.
Shuhao Zhu, P. Romano, R. Wek
semanticscholar   +1 more source

Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress

iScience, 2019
Summary: The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α ...
Marisa Sanchez, Yingying Lin, Chih-Cheng Yang, Philip McQuary, Alexandre Rosa Campos, Pedro Aza Blanc, Dieter A. Wolf   +6 more
doaj   +1 more source

Mitochondrial Dysfunction and Stress Responses in Alzheimer’s Disease

Biology, 2019
Alzheimer’s disease (AD) patients display widespread mitochondrial defects. Brain hypometabolism occurs alongside mitochondrial defects, and correlates well with cognitive decline.
Ian Weidling, Russell H. Swerdlow
doaj   +1 more source

eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress

Molecules and Cells
: Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, which regulates all 3 unfolded protein response pathways, helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational ...
Hien Thi Le, Jiyoung Yu, Hee Sung Ahn, Mi-Jeong Kim, In Gyeong Chae, Hyun-Nam Cho, Juhee Kim, Hye-Kyung Park, Hyuk Nam Kwon, Han-Jung Chae, Byoung Heon Kang, Jeong Kon Seo, Kyunggon Kim, Sung Hoon Back   +13 more
doaj   +1 more source

Proteins of the Nucleolus of Dictyostelium discoideum: Nucleolar Compartmentalization, Targeting Sequences, Protein Translocations and Binding Partners

Cells, 2019
The nucleoli of Dictyostelium discoideum have a comparatively unique, non-canonical, localization adjacent to the inner nuclear membrane. The verified nucleolar proteins of this eukaryotic microbe are detailed while other potential proteins are ...
Danton H. O’Day
doaj   +1 more source