Results 101 to 110 of about 5,879,476 (365)

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

COMP Report: CPQR technical quality control guidelines for use of positron emission tomography/computed tomography in radiation treatment planning

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Positron emission tomography with x‐ray computed tomography (PET/CT) is increasingly being utilized for radiation treatment planning (RTP). Accurate delivery of RT therefore depends on quality PET/CT data. This study covers quality control (QC) procedures required for PET/CT for diagnostic imaging and incremental QC required for RTP.
Ran Klein, Mike Oliver, Dan La Russa, John Agapito, Stewart Gaede, JeanPierre Bissonnette, Arman Rahmim, Carlos Uribe   +7 more
wiley   +1 more source

Chalk cliff retreat in East Sussex and Kent 1870s to 2001 [PDF]

, 2006
The retreat of chalk cliffs fringing the eastern English Channel contributes shingle to the beaches which helps to protect the cliffs and slow down erosion. Conversely, cliff retreat endangers settlements and infrastructure on the clifftop.
Anders F. J., Cherith Moses, Costa S., David A. Robinson, Dornbusch U., May V., May V., Moore L. J., Rendel Williams, Stéphane Costa, Thieler E. R., Thorburn A., Uwe Dornbusch, Valentin H.   +13 more
core   +2 more sources

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Evaluation of patient doses for routine digital radiography procedures toward establishing an institutional diagnostic reference levels: A case study in Sri Lanka

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract The present study was conducted as part of a comprehensive work to establish National Diagnostic Reference Levels (NDRLs) in Sri Lanka for the first time. DRLs can be used as an effective optimization tool for identifying unusually high or low patient doses during X‐ray examinations.
Sachith Welarathna, Sivakumar Velautham, Mihira Wanninayake, Sivananthan Sarasanandarajah   +3 more
wiley   +1 more source

Unconventional magnetoresistance and resistivity scaling in amorphous CoSi thin films

Scientific Reports
The resistivity scaling of Cu electrical interconnects represents a critical challenge in Si CMOS technology. As interconnect dimensions reach below 10 nm, Cu resistivity increases significantly due to surface scattering.
Lorenzo Rocchino, Alan Molinari, Igor Kladaric, Federico Balduini, Heinz Schmid, Marilyne Sousa, John Bruley, Holt Bui, Bernd Gotsmann, Cezar B. Zota   +9 more
doaj   +1 more source

The new corporation in Europe [PDF]

This Policy Brief examines how Europeâ??s corporations are changing the way they do business since the 2004 EU Enlargement. Dalia Marin argues that firms are adapting to heightening global competition by shifting decision-making processes.
Dalia Marin
core   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Highly reproducible and CMOS-compatible VO2-based oscillators for brain-inspired computing

Scientific Reports
With remarkable electrical and optical switching properties induced at low power and near room temperature (68 °C), vanadium dioxide (VO2) has sparked rising interest in unconventional computing among the phase-change materials research community.
Olivier Maher, Roy Bernini, Nele Harnack, Bernd Gotsmann, Marilyne Sousa, Valeria Bragaglia, Siegfried Karg   +6 more
doaj   +1 more source

Europe should stop taxing innovation [PDF]

In this Policy Brief, Bruegel Senior Fellow Bruno van Pottelsberghe makes the argument in favour of a single EU patent system. The author explains that the absence of a one-stop-shop for EU-wide patents hampers innovation and will pose serious challenges
Bruno van Pottelsberghe
core   +1 more source