Results 51 to 60 of about 2,068,953 (291)

Identification of the Areas at High Pluvial Flood Risk Based on Urban Hydraulic Modelling. Case Study for Tulcea Municipality

Modelling in Civil Environmental Engineering, 2023
Pluvial floods are frequent phenomena in Romania occurring during torrential rainfall, causing significant damage. Pluvial floods occur due to extreme rainfall when the natural infiltration of excess water into the ground is artificially reduced and when
Dan Marinela Teodorescu, Hodson Gavin, Lee Rebecca, Speak Ben, Rădulescu Daniela, Rizea Cristina, Cozma Andrei   +6 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The impact of the National Institute for Health Research Health Technology Assessment programme, 2003–13: a multimethod evaluation

Health Technology Assessment, 2015
Background: The National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme supports research tailored to the needs of NHS decision-makers, patients and clinicians. This study reviewed the impact of the programme, from 2003
Susan Guthrie, Teresa Bienkowska-Gibbs, Catriona Manville, Alexandra Pollitt, Anne Kirtley, Steven Wooding   +5 more
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Foundation models for materials discovery – current state and future directions

npj Computational Materials
Large language models, commonly known as LLMs, are showing promise in tacking some of the most complex tasks in AI. In this perspective, we review the wider field of foundation models—of which LLMs are a component—and their application to the field of ...
Edward O. Pyzer-Knapp, Matteo Manica, Peter Staar, Lucas Morin, Patrick Ruch, Teodoro Laino, John R. Smith, Alessandro Curioni   +7 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Collaborative artificial intelligence system for investigation of healthcare claims compliance

Scientific Reports
Healthcare fraud, waste and abuse are costly problems that have huge impact on society. Traditional approaches to identify non-compliant claims rely on auditing strategies requiring trained professionals, or on machine learning methods requiring labelled
Marco Luca Sbodio, Vanessa López, Thanh Lam Hoang, Theodora Brisimi, Gabriele Picco, Inge Vejsbjerg, Valentina Rho, Pol Mac Aonghusa, Morten Kristiansen, John Segrave-Daly   +9 more
doaj   +1 more source

Learning for the NHS on procurement and supply chain management: a rapid evidence assessment

Health Services and Delivery Research, 2014
Background: Procurement of clinical and non-clinical goods has been identified as one area for efficiency savings for the NHS. There is a need for robust evidence to help the NHS make informed decisions about how to make such savings and there is ...
Saba Hinrichs, Deepa Jahagirdar, Céline Miani, Benoit Guerin, Ellen Nolte   +4 more
doaj   +1 more source

Psychotherapy in Europe [PDF]

History of the Human Sciences, 2018
Psychotherapy was an invention of European modernity, but as the 20th century unfolded, and we trace how it crossed national and continental borders, its goals and the particular techniques by which it operated become harder to pin down. This introduction briefly draws together the historical literature on psychotherapy in Europe, asking comparative ...
openaire   +3 more sources