Results 51 to 60 of about 6,711,797 (295)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The impact of the National Institute for Health Research Health Technology Assessment programme, 2003–13: a multimethod evaluation

Health Technology Assessment, 2015
Background: The National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme supports research tailored to the needs of NHS decision-makers, patients and clinicians. This study reviewed the impact of the programme, from 2003
Susan Guthrie, Teresa Bienkowska-Gibbs, Catriona Manville, Alexandra Pollitt, Anne Kirtley, Steven Wooding   +5 more
doaj   +1 more source

Pathogenicity of Different Betanodavirus RGNNV/SJNNV Reassortant Strains in European Sea Bass [PDF]

, 2022
Lorena Biasini, Paola Berto, Miriam Abbadi, Alessandra Buratin, Marica Toson, Andrea Marsella, Anna Toffan, Francesco Pascoli   +7 more
openalex   +1 more source

Water in Europe [PDF]

, 2008
An overview of trends in the water sector in Europe and the companies ...
Hall, David, Lobina, Emanuele
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Foundation models for materials discovery – current state and future directions

npj Computational Materials
Large language models, commonly known as LLMs, are showing promise in tacking some of the most complex tasks in AI. In this perspective, we review the wider field of foundation models—of which LLMs are a component—and their application to the field of ...
Edward O. Pyzer-Knapp, Matteo Manica, Peter Staar, Lucas Morin, Patrick Ruch, Teodoro Laino, John R. Smith, Alessandro Curioni   +7 more
doaj   +1 more source

The transformation of European welfare states and its implications for social work (research): staying on the tanker or choosing a small sloop? [PDF]

, 2023
Koen Hermans, Griet Roets
openalex   +1 more source

Welcome to Europe [PDF]

Bruegel Fellow Jakob von Weizsäcker argues that Europe needs more high-skilled migration and the debate on low-skilled migration should not be an excuse to slow this process down.
Jakob von Weizsäcker
core   +1 more source

Deaths Exceed Births in Most of Europe, But Not in the United States [PDF]

, 2015
In this brief, authors Kenneth Johnson, Layton Fields, and Dudley Poston, Jr. present important new findings about the diminishing number of births compared to deaths in Europe and the United States from their recent article in Population and Development
Fields, Layton M., Johnson, Kenneth M., Poston, Dudley L., Jr.   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source