Results 81 to 90 of about 6,679,772 (342)
Global governance: an agenda for Europe [PDF]
Governance of the global economy is becoming a pressing matter and the situation is compounded by the growing number and diversity of players in the global economy. The authors argue that Europe is now in a position to take a leading role. Not only is it
Alan Ahearne +3 more
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Highly reproducible and CMOS-compatible VO2-based oscillators for brain-inspired computing
Scientific ReportsWith remarkable electrical and optical switching properties induced at low power and near room temperature (68 °C), vanadium dioxide (VO2) has sparked rising interest in unconventional computing among the phase-change materials research community.
Olivier Maher +6 more
doaj +1 more source
Fighting Counterfeit Medicines in Europe: The Effect on Access to Medicines
Medicine Access @ Point of Care, 2017 The implementation of the Falsified Medicines Directive, and its Delegated Regulation with detailed specifications of safety features, will provide an additional obstacle for counterfeiters.
Maarten Van Baelen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Growing strings in a chemical reaction space for searching retrosynthesis pathways
npj Computational MaterialsMachine learning algorithms have shown great accuracy in predicting chemical reaction outcomes and retrosyntheses. However, designing synthesis pathways remains challenging for existing machine learning models which are trained for single-step prediction.
Federico Zipoli +4 more
doaj +1 more source
Beyond the crisis: prospects for emerging Europe [PDF]
This working paper by Zsolt Darvas assesses the impact of the 2008-09 global financial and economic crisis on the medium-term growth prospects of CEES countries, the Caucasus and Central Asia, which starting their economic transition about twenty years ...
Zsolt Darvas
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Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
The inherent adversarial robustness of analog in-memory computing
Nature CommunicationsA key challenge for deep neural network algorithms is their vulnerability to adversarial attacks. Inherently non-deterministic compute substrates, such as those based on analog in-memory computing, have been speculated to provide significant adversarial ...
Corey Lammie +4 more
doaj +1 more source
A first-of-its-kind multi-model convection permitting ensemble for investigating convective phenomena over Europe and the Mediterranean [PDF]
, 2018 Erika Coppola +53 more
openalex +1 more source