Results 31 to 40 of about 202,649 (296)

Pre-emptive depoliticisation: the European Commission and the EU foreign investment screening regulation [PDF]

, 2023
Anna Vlasiuk Nibe, Sophie Meunier, Christilla Roederer‐Rynning   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Landscape features support natural pest control and farm income when pesticide application is reduced

Nature Communications
Future trajectories of agricultural productivity need to incorporate environmental targets, including the reduction of pesticides use. Landscape features supporting natural pest control (LF-NPC) offer a nature-based solution that can serve as a partial ...
Ana Klinnert, Ana Luisa Barbosa, Rui Catarino, Thomas Fellmann, Edoardo Baldoni, Caetano Beber, Jordan Hristov, Maria Luisa Paracchini, Carlo Rega, Franz Weiss, Peter Witzke, Emilio Rodriguez-Cerezo   +11 more
doaj   +1 more source

Medical radionuclide research activities at JRC-Geel [PDF]

EPJ Web of Conferences
A programme to study photon- and neutron-induced reactions of medical interest, as well as accelerator-based methods of medical radionuclide production, has been instituted at JRC-Geel, making use of both existing and new infrastructure.
Tsinganis Andrea, Crespo Pablo Serra, Plompen Arjan, Heyse Jan, Oberstedt Stephan, Moreno Ana Ruiz, Fumagalli Francesco   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Development of a spatial risk indicator for monitoring residential pesticide exposure in agricultural areas

Scientific Reports
The global increase in pesticide use has raised concerns about its impact on biodiversity, ecosystems, and human health, in particular of people living near agricultural areas.
Francesco Galimberti, Stephanie K. Bopp, Alessandro Carletti, Rui Catarino, Martin Claverie, Pietro Florio, Alessio Ippolito, Arwyn Jones, Flavio Marchetto, Michael Olvedy, Alberto Pistocchi, Astrid Verhegghen, Marijn van der Velde, Diana Vieira, Raphaël d’Andrimont   +14 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Emissions of pesticides in the European Union: a new regional-level dataset

Scientific Data, 2023
We present a European Union (EU)-wide dataset of estimated quantities of active substances of plant protection product applied on crops (also called “emissions”).
Angel Udias, Francesco Galimberti, Chiara Dorati, Alberto Pistocchi   +3 more
doaj   +1 more source