Results 41 to 50 of about 46,414 (311)

European Political Parties and the Project of European Constitution. Comparison of Attitudes of the European People's Party and the Party of European Socialists and Their Effect on the Process of Preparation of the Project of European Constitution

Czech Journal of International Relations, 2004
The article focuses on the research of the role of European political parties during the process of preparation of European constitution by the Convention on the future of Europe. Its objective is to verify two hypotheses.
Petr Fiala, Petr Kaniok, Markéta Pitrová   +2 more
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Forum Acusticum 1996 – The 1st Convention of the European Acoustics Associaction EAA Antwerpen, Belgium 1-4 April 1996

Archives of Acoustics, 2014
FORUM ACUSTICUM 1996, the first Convention of the European Acoustics Association EAA-EEIG, is to be held on the campus of the University of Antwerpia, U.I.A. Belgium from 1 to 4 April, 1996. In order to ensure a high quality convention and a large number
Editorial Board Archives of Acoustics
doaj  

THE ARREST PROCEDURE IN ACCORDANCE WITH THE DEMANDS OF THE CONVENTION [PDF]

Challenges of the Knowledge Society, 2016
In order to arrest an individual certain criminal procedural formal and basic conditions must be met. However, due to our country's ratification of the European Convention on Human Rights, besides this criteria, it is also necessary that our domestic law
George Octavian NICOLAE
doaj  

Sur la genèse de la convention de Malte

Archéopages, 2008
The 1992 Malta Convention has caused profound changes in the practice of archaeology in Europe. It is the end-result of a long process that started in the London Convention of 1969, the first European convention to address the question of protecting the ...
Willem J. H. Willems
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Features of application of practice of the european court of human rights.

Теорія і практика правознавства, 2016
The question on application of practice of the European Court of Human Rights. The researcher conducts critical analysis of the Law of Ukraine «On the execution of decisions and application of the practice of the European Court of Human Rights».
В. П. Кононенко
doaj   +1 more source

Implementation of standards of the european convention on human rights regarding forced removal of aliens in the European Union law

Московский журнал международного права, 2020
INTRODUCTION. The global migration crisis taking place in the world and especially within the European Union provokes debates regarding the necessity to change the current approaches to the regulation of migration issues.
E. A. Torkunova, K. G. Zharinov
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source