Results 31 to 40 of about 72,519,190 (299)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The European Court of Human Rights and the Hague Child Abduction Convention:prioritising return or reflection? [PDF]
, 2015 Over the last four decades the 1980 Hague Convention has provided for the prompt return of children to their State of habitual residence. But now that wrongful removals and retentions are most often carried out by primary carers, the majority of whom ...
McEleavy, Peter, Peter McEleavy
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The European Convention on Human Rights: A Socio-Economic Rights Charter? [PDF]
, 2014 The European Court of Human Rights has shown significant weariness in interpreting the European Convention on Human Rights (ECHR) as protecting socio-economic rights. Issues of political legitimacy, judicial proprietary and resource allocation would play
Thornton, Liam
core
Prohibition of Reservation to the Principle of Non-Refoulement of Refugees in the Jurisprudence of the European Court of Human Rights [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒UmūmīIntroductionAsylum-seeking has emerged as a critical social issue at the international level in recent decades. Every year, millions of refugees leave their home countries or places of residence, seeking refuge in other countries to escape economic ...
Mohammad Reza Mogadasifar +1 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Human rights culture: solidarity, diversity and the right to be different [PDF]
, 2005 The concept of a human rights culture has been crucial to the incorporation of the European Convention of Human Rights into UK law. In this paper media and activist representations of human rights for lesbian, gay, bisexual and transgender human rights ...
Nash, Kate
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Московский журнал международного права, 2010 Decision of the European Court of Human Rights on inadmissibility of the Bancovic and others application has given rise to many questions on possibility to apply Convention on protection of human rights and fundamental freedoms to the extraterritorial ...
V. N. Rusinova
doaj +1 more source
German Law Journal, 2020 The Federal Constitutional Court has decided that the prohibition to strike for career civil servants, as it has traditionally been part of the German legal order, is in compliance with the German Constitution.
Matthias Jacobs, Mehrdad Payandeh
doaj +1 more source