Results 51 to 60 of about 24,528 (305)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The European Convention on Human Rights

open access: yesEIRP Proceedings, 2015
Since 1950 - when it was ratified – the European Convention on Human Rights has had a decisive impact on the legislation, jurisprudence and judicial practice of the signatory States of its text.
Cătălina Mititelu
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

RECOGNITION OF VIOLATIONS OF WOMEN’S HUMAN RIGHTS UNDER THE EUROPEAN CONVENTION ON HUMAN RIGHTS IN THE CONTEXT OF RESTRICTIVE ABORTION REGIMES [PDF]

open access: yes, 2011
This thesis considers the possibility that the European Court of Human Rights is developing a role in relation to the restriction of access to abortion services, and impairment of health-care provision linked to such restriction, in Poland and Ireland ...
FENWICK, DANIEL,PATRICK
core  

British exceptionalism, human rights and the accountability of the state in the case of Bloody Sunday in Northern Ireland

open access: yesRevue LISA
This contribution looks at a famous case, Bloody Sunday, through the lens of Article 2 rights (the “right to life”, whether in the European Convention on Human Rights or in the Human Rights Act).
Charlotte Barcat
doaj   +1 more source

HUMAN BEINGS TRAFFICKING IN THE EUROPEAN COURT OF HUMAN RIGHTS CASE-LAW [PDF]

open access: yesChallenges of the Knowledge Society, 2017
After last year’s analysis regarding the European Union’s commitment to fight against the human beings trafficking, we have considered to further explore the human beings trafficking approach in the European Court of Human Rights case-law, the most ...
Laura-Cristiana SPĂTARU-NEGURĂ
doaj  

Features of application of practice of the european court of human rights.

open access: yesТеорія і практика правознавства, 2016
The question on application of practice of the European Court of Human Rights. The researcher conducts critical analysis of the Law of Ukraine «On the execution of decisions and application of the practice of the European Court of Human Rights».
В. П. Кононенко
doaj   +1 more source

Problems with the Turkish Translations of the Convention for the Protection of Human Rights and Fundamental Rights

open access: yesCeza Hukuku ve Kriminoloji Dergisi, 2021
This study analyzes Turkish translations of the Convention for Protection of Human Rights and Fundamental Freedoms, the official versions of which are in English and French. Nine different Turkish translations of this document have been identified.
Tolga Şirin
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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