Results 41 to 50 of about 442,430 (312)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

British exceptionalism, human rights and the accountability of the state in the case of Bloody Sunday in Northern Ireland

open access: yesRevue LISA
This contribution looks at a famous case, Bloody Sunday, through the lens of Article 2 rights (the “right to life”, whether in the European Convention on Human Rights or in the Human Rights Act).
Charlotte Barcat
doaj   +1 more source

HUMAN BEINGS TRAFFICKING IN THE EUROPEAN COURT OF HUMAN RIGHTS CASE-LAW [PDF]

open access: yesChallenges of the Knowledge Society, 2017
After last year’s analysis regarding the European Union’s commitment to fight against the human beings trafficking, we have considered to further explore the human beings trafficking approach in the European Court of Human Rights case-law, the most ...
Laura-Cristiana SPĂTARU-NEGURĂ
doaj  

The European Convention on Human Rights and the economic crisis : the issue of poverty [PDF]

open access: yes, 2013
Distinguished Lecture delivered on the occasion of the XXIV Human Rights Law course of the Academy of European Law, on 24 June 2013.The European Convention on Human Rights is more than ever our common heritage (patrimoine commun) and we share in this ...
TULKENS, Françoise
core  

Sexualities and the ECHR: Introducing the Universal Sexual Legal Subject [PDF]

open access: yes, 2003
Shifting from an essentialist to a constructionist perspective on sexual identities, I move from a consideration of the homosexual legal subject, as presently treated under the European Convention on Human Rights, to the elaboration of a universal sexual
Grigolo, M
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The European Convention on Human Rights

open access: yesEIRP Proceedings, 2015
Since 1950 - when it was ratified – the European Convention on Human Rights has had a decisive impact on the legislation, jurisprudence and judicial practice of the signatory States of its text.
Cătălina Mititelu
doaj  

Review of a textbook: Abashidze A.H., Alisievich E.S. The Law of the European Council. Convention on the Protection of Human Rights and Fundamental Freedoms. 2007, 304 pp.

open access: yesМосковский журнал международного права, 2008
Russia’s accession to European standards of human rights and freedom is a very complicated process and the mechanism of implementation of the European Convention on the protection of human rights and fundamental freedoms is far from ideal.
A. M. Nikolaev
doaj   +1 more source

Police powers and human rights in the context of terrorism [PDF]

open access: yes, 2006
Purpose – The object of the paper is to analyse the justifications for the modification of police powers in response to terrorist threats, placing this issue in a European context.
Pamela M. Barnes, Richard Stone
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

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