Results 121 to 130 of about 9,180,412 (397)
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
EU Energy Policies Targeting the Environment [PDF]
Global Economic Observer, 2014 Activities in the energy sector provide the greatest contribution to the emission of greenhouse gases (GHG), which are assigned primary responsibility for producing climate change.
PAUL CALANTER
doaj
The role of the public service broadcasting in the european countries [PDF]
Broadcasting in particular has seen remarkable change from the days of single-channel public broadcasting systems. The audiovisual “explosion” is a cultural, social and economic phenomenon of global dimension.
Budacia Elisabeta Andreea
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
How and why party position estimates from manifestos, expert, and party elite surveys diverge: A comparative analysis of the 'left-right' and the 'European integration' dimensions. [PDF]
Party Politics, 2022 Ecker A +3 more
europepmc +1 more source
CHALLENGES FOR ROMANIAN ECONOMY AS AN EUROPEAN UNION MEMBER STATES [PDF]
Romanian economy is in an ongoing transformation process starting with 1990. These involve changes of legislation, institutions, human perceptions of economic activity and productivity in order to fulfill the new challenges.
Campeanu Emilia, Mosteanu Tatiana
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
The impact of the controversies within the contemporary world economy onto the regional economic integration and international trade – [PDF]
Following the new position of Romania as a member state of the EU, I consider it imperiously necessary knowing and approaching the problem of the nowadays phenomena the world trade and the world economy are confronting, EU according to today statistics ...
Giurgiu Adriana
core
Aging and Cancer, EarlyView.This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha +4 more
wiley +1 more source