Results 41 to 50 of about 65,573 (238)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Tragedija slovenskega nacionalnega patentnega sistema
Economic and Business Review, 2019 The current Slovenian national patent system is supposed to provide incentives for innovation activity in the Slovenian economy while preventing the granting of unjustified monopolies, but the question arises whether this is the case.
Mitja Kovač, Rok Spruk
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Patenting in Europe: The Jurisdiction of the CJEU over European Patent Law
Perspectives on Federalism, 2015 This paper will deal with EU competence over patent law, especially in the context of the TRIPS Agreement with reference to the ruling of CJEU in the Daiichi Sankyo case (CJEU case C-414/11 Daiichi Sankyo v DEMO Anonimos). The first part will explain the
Minn Mari
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2015 The patent eligibility of stem cells – particularly those derived from human embryos – has long been under debate in both the scientific and legal communities.
Sonya eDavey +11 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Is Poland an Innovative Country?
Management Systems in Production Engineering, 2018 The potential for innovativeness is difficult to measure, though many have attempted to do so. In order to look at Poland’s innovation potential, its current position and its opportunity to grow, compared with developing and developed countries, this ...
Chybowska Dorota +2 more
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Brexit – What are the potential consequences for pharma patents and SPCs
British Journal of Pharmacy, 2017 Brexit raises a number of difficult questions with regard to intellectual property rights in a post-Brexit world, particularly for UK based pharma companies.
Jamie Fraser, James Stones
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