Results 61 to 70 of about 69,467 (236)

Cross-Border Patent Disputes: Unified Patent Court or International Commercial Arbitration?

open access: yesUtrecht Journal of International and European Law, 2016
Currently, the enforcement of a patent that is registered in several countries involves the risk of getting different and conflicting decisions from the national courts.
Ana Alba Betancourt
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Nano is nano is nano or: nanotechnology – a European legal perspective

open access: yesNanotechnology Reviews, 2014
In Europe, nanotechnology is perceived as one of the innovative technologies that may drive technological progress. At the same time, Europe historically has followed an approach to cautiously but proactively regulate new technologies, instead of taking ...
Fulda Christian   +2 more
doaj   +1 more source

The reflection of the struggle of Russian companies for promising markets in the patent statistics

open access: yesEkonomika Nauki, 2017
The article analyzes data from the annual report of the European patent agency, reflecting the struggle of industrialized countries for the EU market in the projection of the patent landscape of 2016.
N. G. Kurakova
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Patenting of technologies related to renewable energy: the case of biodiesel

open access: yesRevista Tecnologia, 2010
In this work a study of technological tendencies in biodiesel was carried out, based on information extracted of patent documents. The term “patent document” covers published patent applications or granted patents.
Márcia França Fernandes dos Santos   +2 more
doaj  

Unitary Patent and the Unified Patent Court: Attractive for SMEs?

open access: yesCroatian Yearbook of European Law and Policy
The Unitary Patent Package (UPP) was conceived as a means of simplifying and centralising patent protection and enforcement across participating EU Member States. The introduction of a supranational patent jurisdiction and a unitary protection system was
Ivana Božac
doaj   +1 more source

Patent Applications on Representative Sectors of Biotechnology in Brazil: an Analysis of the Last Decade

open access: yesJournal of Technology Management & Innovation, 2013
The present article aims to assess the innovative activity in the Brazilian most representative sector in biotechnology field. The search was conducted through patent applications of residents at the National Institute of Industrial Property (INPI ...
Liliana Machado Mendes   +2 more
doaj   +1 more source

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