Results 31 to 40 of about 691,418 (294)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
QUANTIFYING POLYCENTRIC PATTERNS: AN EMPIRICAL APPLICATION ON EMPLOYMENT DATA IM MOLDOVA, ROMANIA
European Journal of Geography, 2023 Polycentrism has been in the academic limelight ever since it was promoted in European Spatial Development Perspective as an a-priori view valuable to adopt.
Alexandra BLĂGEANU
doaj +2 more sources
Co-ordinating European sectoral policies against the background of European Spatial Development [PDF]
, 2005 Repeated demands by both the European Parliament and the EU Member States nonwithstanding, responsibility for European spatial development policy remains unclear.
Schäfer, Nicole
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Belgeo, 2000 The European Union is promoting a policy of balanced and sustainable spatial development planning. Spatial planning ministers have recently adopted a spatial development perspective for the European Union territory, which is proposing a spatial vision ...
Valérie Biot, Alain Colard
doaj +1 more source
What “Is” Territorial Cohesion? What Does It “Do”?: Essentialist Versus Pragmatic Approaches to Using Concepts [PDF]
, 2013 The question, “what is territorial cohesion” has reverberated through European spatial policy since the publication of the European Spatial Development Perspective in 1999.
Abrahams, Gareth
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
“IMPLEMENTING LOCAL DEVELOPMENT STRAT EGIES” WITHIN AXIS 4. RDP 2007-2013 –SPATIA L DIVERSIFICATION OF LEVEL AND STRUCTURE OF LEADER FUNDS DELIVERY [PDF]
Annals of the Polish Association of Agricultural and Agribusiness Economists, 2018 The aim of the study was to assess the spatial diversification of the level and structure of deliveryof the funds available within measure ‘Implementing Local Development Strategies’ under axis 4 of theRDP 2007-2013.
Roman Rudnicki +2 more
doaj +1 more source