Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Recalcitrance, Inefficiency, and Support for European Integration: Why Member States Do (Not) Comply with European Law. CES Working Paper, no. 151, 2007 [PDF]
, 2007 This paper seeks to explain inter-state variation in non-compliance with European law. While non-compliance has not significantly increased over time, some member states violate European law more frequently than others.
Sprungk, Carina. +4 more
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translating EU civil protection in the Nordic states – towards a theoretical understanding of the creation of European crisis management capacities. [PDF]
, 2007 This paper analyses how EU civil protection is translated (both in a linguistic/conceptual sense and in an organisational sense) in the Nordic states. The analysis builds on interviews with civil servants and illustrates how European crisis management ...
Britz, Malena.
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Nordic States and European Integration : Awkward Partners in the North?
, 2018 This book provides the first lengthy study of awkward states/partners in regional integration. Is awkwardness a characteristic of states in many global regions, or is it reducible to the particular case of the United Kingdom in European integration?
Brianson, Alex +3 more
core +1 more source
Frontiers in Astronomy and Space SciencesThe dayside particle precipitation during the passage of a solar wind rotational discontinuity (RD) event on 10 April 2015 is examined and reviewed. The RD leads to complex structures at the magnetopause, boundary layer, mantle, and cusp even though the ...
Simon Wing +3 more
doaj +1 more source
Conducting national burden of disease studies and knowledge translation in eight small European states: challenges and opportunities. [PDF]
Health Res Policy Syst, 2022 Cuschieri S +11 more
europepmc +1 more source