Results 81 to 90 of about 8,646,404 (308)

Femtogram Electroanalytical Detection of Prostatic Specific Antigen by Brdicka Reaction

open access: yesInternational Journal of Electrochemical Science, 2012
Prostatic-specific antigen is considered as the best marker for prostate cancer. Due to the importance of PSA for diagnostic purposes it is not surprising that there are tested and optimized various methods for its determination.
David Hynek   +12 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Andorra and the European Union. CEPS Paperbacks. December 2007 [PDF]

open access: yes, 2007
This study has been prepared for the Andorran Minister of Foreign Affairs in order to assess possible futures for Andorran-EU relations over the short to longer ...
Emerson, Michael
core  

Electrochemical Characterization of Various Synthesized Quantum Dots and the Effect of Aging and Storage Way

open access: yesInternational Journal of Electrochemical Science, 2015
New type of quantum dots (QDs) are synthesized using various types of passivators, thus the question of their stability and way of storage is still opened not only due to characterization but also due to their wide application (chemistry, chemical ...
David Hynek   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Influencing Policy Production in the European Union: The European Commission Before the Court of Justice [PDF]

open access: yes, 2009
The present paper addresses the role of the European Commission in shaping policy produced in the European Union. Most related studies have focussed on the Commission’s positions in legislative or executive politics.
Hofmann, Andreas
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

How the European Union Interacts with its Member States. IHS Political Science Series: 2003, No. 93 [PDF]

open access: yes, 2003
The paper seeks to identify concepts and theories to analyze and explain the relationship between the Member States and the European Union. It mainly adopts a top-down perspective looking at how the European Union has affected the Member States and to ...
Börzel, Tanja A.
core  

Electrochemical Study of Doxorubicin Interaction with Different Sequences of Single Stranded Oligonucleotides, Part I

open access: yesInternational Journal of Electrochemical Science, 2012
Doxorubicin is a known anticancer drug intercalating into dsDNA. The mechanism of interaction of doxorubicin with ssDNA is not clear. In this study, adsorptive transfer stripping technique coupled with square wave voltammetry was used for studying of ...
David Hynek   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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