Results 61 to 70 of about 354,025 (268)

Botulism in the European Union

Eurosurveillance, 1999
Botulinum toxin was first described as a potent neurotoxin in the late eighteenth century. Currently three main distinct clinical and epidemiological botulism syndromes are described - foodborne botulism, which results from the ingestion of food ...
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ACL injury prevention in European women’s football: exploring knowledge, attitudes and practices in a cross-sectional study

BMJ Open Sport & Exercise Medicine
Objective To assess the knowledge, attitudes and behaviours regarding anterior cruciate ligament (ACL) injury prevention among individuals involved in women’s football at all levels, including players and staff across Union of European Football ...
Evert Verhagen, Katrine Okholm Kryger, Gabriel Monthuley   +2 more
doaj   +1 more source

The Electrochemical and Statistical Evaluation of Isolation of Mellitin and Apamin from Honey Bee (Apis Mellifera) Venom

International Journal of Electrochemical Science, 2015
We present in this manuscript for the first time the electrochemical and statistical evaluation of FPLC isolation of mellitin and apamin from honey bee (Apis mellifera) venom. Venoms are extremely complex blends of diverse substances that target a myriad
Hoai Viet Nguyen, Zbynek Heger, Marketa Kominkova, Petr Michalek, Jaromir Gumulec, Roman Guran, Antonin Pridal, Carlos Fernandez, David Hynek, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Y-Fe2O3 Magnetic Core Functionalized with Tetraethyl Orthosilicate and 3-Aminopropyl Triethoxysilane for an Isolation of H7N7 Influenza Serotype Virions

International Journal of Electrochemical Science, 2014
The influenza viruses cause annual epidemics of respiratory disease and occasional pandemics, which constitute a major public-health issue. The most important tool in the diagnosis of influenza pandemic is timely and right diagnosis.
Zbynek Heger, Natalia Cernei, Roman Guran, Petr Michalek, Vedran Milosavljevic, Pavel Kopel, Ondrej Zitka, Jindrich Kynicky, Petr Lany, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

European Union Litigation

European Review of Contract Law, 2017
Abstract This article provides an overview of cases decided by the Court of Justice of the European Union concerning contract law. The present issue covers the period between the beginning of July 2019 and the end of December 2019.
ESPOSITO, Fabrizio, HACKER, Philipp
openaire   +4 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Characterization of Carbon Dots Covered with Polyvinylpyrrolidone and Polyethylene Glycol

International Journal of Electrochemical Science, 2015
Luminescent carbon dots are new type of nanomaterial with possible applications in labelling and imaging due to their optoelectronic properties and their superior biocompatibility.
Jiri Kudr, Lukas Richtera, Lukas Nejdl, Iva Blazkova, Vedran Milosavljevic, Zdenek Moravec, Dorota Wawrzak, Pavel Kopel, Branislav Ruttkay-Nedecky, Vojtech Adam, Rene Kizek   +10 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source