Results 171 to 180 of about 210,115 (312)

Establishment of a novel alloxan‐induced rabbit model exhibiting unique diabetic retinal neuropathy features assessed via ERG + VEP

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Study workflow. Neuroretinal changes were observed in alloxan‐induced diabetic rabbits, while the retinal vasculature remained unaffected, indicating the successful establishment of a diabetic neuroretinal model. Abstract Background Diabetic retinal neuropathy (DRN) leads to significant visual impairment; however, no existing animal model fully ...
Xinlu Li   +9 more
wiley   +1 more source

The case for euthanasia in the Netherlands

open access: bronze, 1992
Peter C. de Jong, Peter J. Kansen
openalex   +1 more source

Long‐term immunosuppression of rabbits through oral tacrolimus administration

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Oral gavage of rabbits with 1.5 mg/kg/d of tacrolimus allows for an efficient long‐term (1 year) immunosuppression with minimal side effects and no loss of animals. lmmunosuppressed rabbits are a convenient animal model to investigate the long‐term efficacy of human allografts in vivo.
Alexane Thibodeau   +4 more
wiley   +1 more source

Attitudes of physicians, nurses, and the general public toward End-of-Life (EoL) decisions in European countries: an umbrella review. [PDF]

open access: yesBMC Med Ethics
Refolo P   +11 more
europepmc   +1 more source

Comparative analysis of two newly established Cre rat lines, NeuN‐Cre and Thy1‐Cre, for neurological research

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li   +15 more
wiley   +1 more source

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage   +4 more
wiley   +1 more source

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