Results 191 to 200 of about 119,088 (258)

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Hemorrhagic Fever Disease in STAT-1 Knockout Mice Infected with Lujo Virus. [PDF]

Pathogens
Johnson DM, Jan S, Dunn E, Comer JE, Cross RW, Geisbert TW.   +5 more
europepmc   +1 more source

Emotional responses of veterinary students to first encounters with animal body donors

Anatomical Sciences Education, EarlyView.
Abstract Students' first encounters with animal body donors in higher education are a formative and also potentially stressful experience. The complex emotions elicited by body donor use in learning and their effects on professional development have been documented in medical students, but are far less explored in veterinary medical counterparts.
S. Regnault, C. Basu, S. Channon
wiley   +1 more source

Techno-Mainstreaming Palliative Care: The Global Palliative Doctors' Network. [PDF]

J Epidemiol Glob Health
Ebrahim SH, Rahman M, Banoo S, Rivera BD, Baylon-Mallillin MM, Begum N, Desh P, Govender T, Badarudeen S, Memish Z, Global Palliative Doctors Network.   +10 more
europepmc   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Preclinical Rat Models in Oral Implant Dentistry: A Scoping Review of Study Design and Experimental Practices. [PDF]

Dent J (Basel)
Podda GM, Borghetti L, De Siati C, Galvez P, Romeo U, Catros S.   +5 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Bifunctional injectable selenium‐containing polyurethane hydrogels for periodontal regeneration through endoplasmic reticulum stress modulation

BMEMat, EarlyView.
Graphical illustration of the synthesis, biological functions and mechanisms of bifunctional injectable selenium‐containing polyurethane hydrogels. Abstract Periodontitis causes progressive destruction of both periodontal soft and hard tissues, leading to tooth loss and functional impairment.
Mingchu Zhao, Mo Zhai, Zhuoxin Ge, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Huaping Xu, Yongsheng Zhou, Longwei Lv   +8 more
wiley   +1 more source

Pathogenesis of Aleutian Mink Disease Virus Infection-Comparison of Natural Transmission with Experimental Aerosol and Intraperitoneal Inoculation. [PDF]

Pathogens
Hansen MS, Chriél M, Larsen LE, Hjulsager CK.   +3 more
europepmc   +1 more source

Celiotomy to collect spermatogonial stem cells in <i>Brycon orbignyanus</i> for species preservation. [PDF]

Anim Reprod
da Silva LG, Torres-Lozano KG, Rodrígues RB, de Freitas TR, Povh JA, Spica LN, Teixeira NDS, Selle DC, Benato JL, Dos Santos RS, Nicoleti ET, Dantas RV, Streit DP.   +12 more
europepmc   +1 more source